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非修饰以及表面修饰的 SiO2 纳米颗粒对红细胞、生物和模型膜的影响。

Effect of Non-Modified as Well as Surface-Modified SiO Nanoparticles on Red Blood Cells, Biological and Model Membranes.

机构信息

Department of Physics and Biophysics, Wrocław University of Environmental and Life Sciences, Norwida St. 25, 50-375 Wrocław, Poland.

Department of Chemistry, Faculty of Science, Humanities and Education, Technical University of Liberec, Studentska 2, 461 17 Liberec, Czech Republic.

出版信息

Int J Mol Sci. 2023 Jul 21;24(14):11760. doi: 10.3390/ijms241411760.

DOI:10.3390/ijms241411760
PMID:37511517
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10380300/
Abstract

Nanoparticles are extremely promising components that are used in diagnostics and medical therapies. Among them, silica nanoparticles are ultrafine materials that, due to their unique physicochemical properties, have already been used in biomedicine, for instance, in cancer therapy. The aim of this study was to investigate the cytotoxicity of three types of nanoparticles (SiO2, SiO2-SH, and SiO2-COOH) in relation to red blood cells, as well as the impact of silicon dioxide nanoparticles on biological membranes and liposome models of membranes. The results obtained prove that hemolytic toxicity depends on the concentration of nanoparticles and the incubation period. Silica nanoparticles have a marginal impact on the changes in the osmotic resistance of erythrocytes, except for SiO2-COOH, which, similarly to SiO2 and SiO2-SH, changes the shape of erythrocytes from discocytes mainly towards echinocytes. What is more, nanosilica has an impact on the change in fluidity of biological and model membranes. The research gives a new view of the practical possibilities for the use of large-grain nanoparticles in biomedicine.

摘要

纳米粒子是极具应用前景的组成部分，被应用于诊断和医疗治疗中。其中，硅纳米粒子是一种超细微粒材料，由于其独特的物理化学性质，已被应用于生物医学领域，例如癌症治疗。本研究旨在研究三种类型的纳米粒子（SiO2、SiO2-SH 和 SiO2-COOH）与红细胞的细胞毒性，以及二氧化硅纳米粒子对生物膜和脂质体模型膜的影响。研究结果表明，溶血毒性取决于纳米粒子的浓度和孵育时间。除了 SiO2-COOH 之外，硅纳米粒子对红细胞渗透抗性的变化影响不大，SiO2-COOH 类似于 SiO2 和 SiO2-SH，主要将红细胞的形状从盘形变为刺形。此外，纳米硅对生物膜和模型膜的流动性变化有影响。本研究为大颗粒纳米粒子在生物医学中的实际应用提供了新的视角。

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