Wu Jih-Huah, Yang Chia-Yen, Chang Yang-Chyuan, Shan Yi-Chia
Department of Biomedical Engineering, Ming Chuan University, No. 5, Deming Rd., Gweishan Township, Taoyuan 333, Taiwan.
Department of Neurology, Min-Sheng General Hospital, No. 168, Jin-Kuo Rd., Taoyuan 330, Taiwan.
Life (Basel). 2023 Jun 30;13(7):1490. doi: 10.3390/life13071490.
In our previous studies, photobiomodulation (PBM) stimulation can induce significant brain activation in normal subjects. In an open-eye study, the PBM stimulation was able to increase the power of alpha rhythms and theta waves, as well as decrease the beta activities after PBM stimulation. However, in the closed eyes study, the alpha rhythms in the laser group were reduced. This means the PBM stimulation can induce specific brainwaves under different conditions. Thus, to investigate the effects of PBM stimulation on human's attention, forty students were recruited in this single-blind randomized trial. A PBM stimulator, with seven pcs laser diodes (LDs), frequency 10 Hz, 30 mW/each LD, and wavelength 830 nm, was used to radiate the palm of the subject. PBM stimulation was found to induce significant variation in beta activity in most of the regions of the brain in the laser group. Compared to the placebo group, the PBM stimulation has a significant change in beta activity on electroencephalography (EEG). Three types of tests, the random number test, the Stroop color-word test, and the Multiple-Dimension Attention Test (MDAT), were used to evaluate the effects of the PBM stimulation. The scores of MDAT in the laser group increased more significantly than those in the placebo group after PBM stimulation ( < 0.01). An improvement in attention was observed in this study.
在我们之前的研究中，光生物调节（PBM）刺激可在正常受试者中诱导显著的大脑激活。在一项睁眼研究中，PBM刺激能够增加阿尔法节律和西塔波的功率，以及在PBM刺激后降低贝塔活动。然而，在闭眼研究中，激光组的阿尔法节律降低。这意味着PBM刺激可在不同条件下诱导特定脑电波。因此，为了研究PBM刺激对人类注意力的影响，在这项单盲随机试验中招募了40名学生。使用一台带有7个激光二极管（LDs）、频率为10Hz、每个LD为30mW且波长为830nm的PBM刺激器照射受试者的手掌。发现PBM刺激在激光组大脑的大多数区域诱导贝塔活动发生显著变化。与安慰剂组相比，PBM刺激在脑电图（EEG）上的贝塔活动有显著变化。使用三种测试，即随机数字测试、斯特鲁普颜色-文字测试和多维注意力测试（MDAT）来评估PBM刺激的效果。PBM刺激后，激光组MDAT的得分比安慰剂组增加得更显著（<0.01）。在本研究中观察到注意力有所改善。
