Tian Ye, Dong Jing, Li Lin
College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China.
Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Shenyang Agricultural University, Shenyang 110866, China.
Life (Basel). 2023 Jul 21;13(7):1599. doi: 10.3390/life13071599.
Breast cancer continuously poses serious clinical challenges to human health due to its intrinsic heterogenicity and evolving drug resistance. Recently, increasing evidence has shown that pyroptosis, known as a programmed and inflammatory form of cell death, participates in tumorigenesis, progression, and remodeling of the tumor immune microenvironment (TIME). However, a comprehensive insight into pyroptosis-related signatures for breast cancer remains elusive. The current study established a pyroptosis-related lncRNA signature using transcriptome data and corresponding clinical information from The Cancer Genome Atlas (TCGA). Pyroptosis-related gene clusters, the associated differential expression in breast cancer patients' subtypes, and the potential mechanisms were all discussed. This integrative analysis revealed a unique signature underpinning the dichotomy of breast cancer progression and survival outcomes. Interestingly, the pyroptosis-related lncRNA signature was revealed as closely intertwined with the TIME. A correlation was established between the pyroptosis-related LncRNA signature and the TIME, underlying the mutual effect between pyroptosis and the immune responses implicated in breast cancer. The findings in this work underline the critical role exerted by pyroptosis in breast cancer, providing new insights into disease progression, prognosis, and therapeutic potential. This work has been poised to provide new avenues for personalized, immune-based cancer therapeutics by enhancing our understanding of pyroptosis in breast cancer.
由于其内在的异质性和不断演变的耐药性，乳腺癌持续对人类健康构成严峻的临床挑战。最近，越来越多的证据表明，焦亡作为一种程序性和炎症性细胞死亡形式，参与肿瘤发生、进展以及肿瘤免疫微环境（TIME）的重塑。然而，对于乳腺癌中焦亡相关特征的全面认识仍然不足。本研究利用来自癌症基因组图谱（TCGA）的转录组数据和相应临床信息，建立了一个焦亡相关lncRNA特征。讨论了焦亡相关基因簇、乳腺癌患者亚型中的相关差异表达以及潜在机制。这种综合分析揭示了一个独特的特征，它是乳腺癌进展和生存结果二分法的基础。有趣的是，焦亡相关lncRNA特征被发现与TIME密切相关。在焦亡相关LncRNA特征与TIME之间建立了一种关联，这揭示了焦亡与乳腺癌中免疫反应之间的相互作用。这项工作的发现强调了焦亡在乳腺癌中的关键作用，为疾病进展、预后和治疗潜力提供了新的见解。通过加强我们对乳腺癌中焦亡的理解，这项工作有望为个性化的、基于免疫的癌症治疗提供新途径。
