Purrmann J, Miller B, Strohmeyer G
Z Gastroenterol. 1986 Jul;24(7):357-63.
Furthermore the aetiopathogenesis of inflammatory bowel disease (IBD) is unknown. The familial accumulation makes a genetic disposition probable. Presumably, the development of Crohn's disease and ulcerative colitis is contingent upon several factors, including perhaps environmental factors in the broadest sense. A large number of microorganisms have been implicated, but there is still no convincing proof that any of them have an important role in the aetiopathogenesis of IBD. The observed immunological phenomena are as yet difficult to interpret.
此外，炎症性肠病（IBD）的病因发病机制尚不清楚。家族性聚集提示可能存在遗传易感性。推测克罗恩病和溃疡性结肠炎的发生取决于多种因素，这可能包括最广义的环境因素。大量微生物被认为与之相关，但仍没有令人信服的证据表明其中任何一种在IBD的病因发病机制中起重要作用。目前观察到的免疫现象仍难以解释。
