Department of Internal Medicine, Division of Rheumatology, Soonchunhyang University Bucheon Hospital, Bucheon 14854, Republic of Korea.
Department of Otorhinolaryngology-Head and Neck Surgery, Sanggye Paik Hospital, College of Medicine, Inje University, Seoul 01757, Republic of Korea.
Medicina (Kaunas). 2023 Jul 9;59(7):1273. doi: 10.3390/medicina59071273.
Hyperuricemia is associated with a variety of comorbidities. The objective of this study was to investigate the association between hyperuricemia and hearing impairment in Korean adults. Audiometric and laboratory test data from the 2019 to 2020 Korean National Health and Nutrition Examination Survey (KNHANES) were used for analysis. Hearing impairment was defined as a pure-tone average (0.5, 1, 2, 4 kHz) threshold level ≥ 41 decibels. The definition of hyperuricemia was different for males and females: >7 mg/dL for males vs. >6 mg/dL for females. A total of 4857 (weight = 17,990,725) subjects were analyzed. The mean age was 56.8 years old. The weighted prevalence was 12.1% for hyperuricemia and 2.5% for gout. The prevalence of hearing impairment was 13.4%. In the univariable analysis, hyperuricemia was significantly associated with hearing impairment. However, the diagnosis of gout was not associated with hearing impairment. In the multivariable analysis, hyperuricemia (odds ratios (OR): 1.41, 95% confidence interval [CI]: 1.03-1.92, = 0.030) was associated with hearing impairment along with age (OR: 1.12, 95% CI: 1.10-1.14, < 0.001), female sex (OR: 0.43, 95% CI: 0.34-0.64, < 0.001), education (OR: 0.43, 95% CI: 0.30-0.63, = 0.001), and occupational noise exposure (OR: 1.67, 95% CI: 1.25-2.22, = 0.001). In the subgroup analysis, hyperuricemia was associated with hearing impairment in females (OR: 1.59, 95% CI: 1.02-2.48, = 0.041) and the elderly aged 60 years or more (OR: 1.45, 95% CI: 1.05-1.99, = 0.023). : Hyperuricemia was independently associated with hearing impairment, especially in females and the elderly aged 60 years or more.
高尿酸血症与多种合并症相关。本研究旨在探讨韩国成年人高尿酸血症与听力损伤之间的关系。分析了 2019-2020 年韩国国家健康与营养调查（KNHANES）的听力测试和实验室检测数据。听力损伤定义为纯音平均听阈（0.5、1、2、4 kHz）水平≥41 分贝。男性和女性的高尿酸血症定义不同：男性>7mg/dL 与女性>6mg/dL。共分析了 4857 名（体重=17990725）受试者。平均年龄为 56.8 岁。高尿酸血症的加权患病率为 12.1%，痛风的加权患病率为 2.5%。听力损伤的患病率为 13.4%。在单变量分析中，高尿酸血症与听力损伤显著相关。然而，痛风的诊断与听力损伤无关。在多变量分析中，高尿酸血症（比值比（OR）：1.41，95%置信区间[CI]：1.03-1.92， = 0.030）与年龄（OR：1.12，95% CI：1.10-1.14， < 0.001）、女性（OR：0.43，95% CI：0.34-0.64， < 0.001）、教育程度（OR：0.43，95% CI：0.30-0.63， = 0.001）和职业性噪声暴露（OR：1.67，95% CI：1.25-2.22， = 0.001）与听力损伤相关。在亚组分析中，高尿酸血症与女性（OR：1.59，95% CI：1.02-2.48， = 0.041）和 60 岁及以上老年人（OR：1.45，95% CI：1.05-1.99， = 0.023）的听力损伤相关。总之，高尿酸血症与听力损伤独立相关，尤其是在女性和 60 岁及以上的老年人中。
