Teixeira Rita Almeida, Silva Cláudia, Ferreira António Carlos, Martins Diana, Leite-Moreira Adelino, Miranda Isabel M, Barros António S
Cardiovascular R&D Centre, UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, Alameda Professor Hernani Monteiro, 4200-319 Porto, Portugal.
Microorganisms. 2023 Jul 4;11(7):1749. doi: 10.3390/microorganisms11071749.
Gestational diabetes, affecting about 10% of pregnancies, is characterized by impaired glucose regulation and can lead to complications for health of pregnant women and their offspring. The microbiota, the resident microbes within the body, have been linked to the development of several metabolic conditions. This systematic review with meta-analysis aims to summarize the evidence on the differences in microbiota composition in pregnant women with gestational diabetes and their offspring compared to healthy pregnancies. A thorough search was conducted in the PubMed, Scopus, and Web of Science databases, and data from 21 studies were analyzed utilizing 41 meta-analyses. In the gut microbiota, Bifidobacterium and Alistipes were found to be more abundant in healthy pregnancies, while Roseburia appears to be more abundant in gestational diabetes. The heterogeneity among study findings regarding the microbiota in the meconium is considerable. The placental microbiota exhibited almost no heterogeneity, with an increased abundance of Firmicutes in the gestational diabetes group and a higher abundance of Proteobacteria in the control. The role of the microbiota in gestational diabetes is reinforced by these findings, which additionally point to the potential of microbiome-targeted therapies. To completely comprehend the interactions between gestational diabetes and the microbiome, standardizing methodologies and further research is necessary.
妊娠期糖尿病影响约10%的妊娠，其特征为葡萄糖调节受损，并可能导致孕妇及其后代出现健康并发症。微生物群是体内的常驻微生物，与多种代谢疾病的发生有关。这项系统评价和荟萃分析旨在总结与健康妊娠相比，妊娠期糖尿病孕妇及其后代微生物群组成差异的证据。我们在PubMed、Scopus和Web of Science数据库中进行了全面检索，并利用41项荟萃分析对21项研究的数据进行了分析。在肠道微生物群中，双歧杆菌和阿利斯杆菌在健康妊娠中更为丰富，而罗斯氏菌在妊娠期糖尿病中似乎更为丰富。关于胎粪中微生物群的研究结果之间的异质性相当大。胎盘微生物群几乎没有异质性，妊娠期糖尿病组厚壁菌门丰度增加，对照组变形菌门丰度更高。这些发现强化了微生物群在妊娠期糖尿病中的作用，此外还指出了针对微生物群的治疗潜力。为了完全理解妊娠期糖尿病与微生物群之间的相互作用，标准化方法和进一步研究是必要的。
