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患有妊娠期糖尿病的接受冷冻胚胎移植的不孕女性孕前微生物群的特征

Signature of pre-pregnancy microbiome in infertile women undergoing frozen embryo transfer with gestational diabetes mellitus.

作者信息

Guan Wenzheng, Zhou Tian, Jiao Jiao, Xiao Liwen, Wang Zhen, Liu Siyuan, Yan Fujie, Zhao Fangqing, Wang Xiuxia

机构信息

Center of Reproductive Medicine, Shengjing Hospital of China Medical University, Shenyang, China.

Shenyang Reproductive Health Clinical Medicine Research Center, Shenyang, China.

出版信息

NPJ Biofilms Microbiomes. 2025 Jan 8;11(1):6. doi: 10.1038/s41522-024-00639-w.

DOI:10.1038/s41522-024-00639-w
PMID:39779730
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11711321/
Abstract

This study aims to evaluate differences in gut microbiota structures between infertile women undergoing frozen embryo transfer (FET) with gestational diabetes mellitus (GDM) and healthy controls (HCs), and to identify potential markers. We comprehensively enrolled 193 infertile women undergoing FET (discovery cohort: 38 HCs and 31 GDM; validation cohort: 85 HCs and 39 GDM). Gut microbial profiles of the discovery cohort were investigated during the pre-pregnancy (Pre), first trimester (T1), and second trimester (T2). The microbial community in the HCs group remained relatively stable throughout the pregnancy, while the microbial structure alteration occurred in the GDM group during T2. A model based on ten bacteria and ten metabolites simultaneously was used to predict the risk of GDM developing in the pre-pregnancy state with the ROC value of 0.712. Algorithms on the basis of marker species and biochemical parameters can be used as effective tools for GDM risk evaluation before pregnancy.

摘要

本研究旨在评估接受冻融胚胎移植（FET）并患有妊娠期糖尿病（GDM）的不孕女性与健康对照（HCs）之间肠道微生物群结构的差异，并确定潜在标志物。我们全面招募了193名接受FET的不孕女性（发现队列：38名HCs和31名GDM；验证队列：85名HCs和39名GDM）。在孕前（Pre）、孕早期（T1）和孕中期（T2）对发现队列的肠道微生物谱进行了研究。HCs组的微生物群落在整个孕期保持相对稳定，而GDM组在T2期出现了微生物结构改变。基于十种细菌和十种代谢物的模型同时用于预测孕前状态下发生GDM的风险，ROC值为0.712。基于标志物种类和生化参数的算法可作为孕前GDM风险评估的有效工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7ef/11711321/7321a6d59d8f/41522_2024_639_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7ef/11711321/2485e4756684/41522_2024_639_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7ef/11711321/f1f95753b437/41522_2024_639_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7ef/11711321/250d552a3bf6/41522_2024_639_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7ef/11711321/be070203a3a6/41522_2024_639_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7ef/11711321/427b9bb0b5d7/41522_2024_639_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7ef/11711321/7321a6d59d8f/41522_2024_639_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7ef/11711321/2485e4756684/41522_2024_639_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7ef/11711321/f1f95753b437/41522_2024_639_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7ef/11711321/250d552a3bf6/41522_2024_639_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7ef/11711321/be070203a3a6/41522_2024_639_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7ef/11711321/427b9bb0b5d7/41522_2024_639_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7ef/11711321/7321a6d59d8f/41522_2024_639_Fig6_HTML.jpg

相似文献

[1]
Signature of pre-pregnancy microbiome in infertile women undergoing frozen embryo transfer with gestational diabetes mellitus.

NPJ Biofilms Microbiomes. 2025-1-8

[2]
Metagenomic analysis reveals gestational diabetes mellitus-related microbial regulators of glucose tolerance.

Acta Diabetol. 2019-12-9

[3]
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BMC Pregnancy Childbirth. 2022-2-24

[4]
Composition of the intestinal microbiota and its variations between the second and third trimesters in women with gestational diabetes mellitus and without gestational diabetes mellitus.

Front Endocrinol (Lausanne). 2023

[5]
Gestational diabetes is associated with change in the gut microbiota composition in third trimester of pregnancy and postpartum.

Microbiome. 2018-5-15

[6]
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Microbiol Spectr. 2025-4

[7]
Differential intestinal and oral microbiota features associated with gestational diabetes and maternal inflammation.

Am J Physiol Endocrinol Metab. 2019-12-31

[8]
Association of gestational diabetes mellitus with changes in gut microbiota composition at the species level.

BMC Microbiol. 2021-5-14

[9]
Characteristics of the gut microbiome in women with gestational diabetes mellitus: A systematic review.

PLoS One. 2022

[10]
Effects of vaginal microbiota on fertilization outcomes in women with different infertility causes.

Microbiol Spectr. 2025-3-4

引用本文的文献

[1]
Gut microbiota development, antibiotic resistome, and related perinatal factors in early infancy.

mSystems. 2025-8-19

本文引用的文献

[1]
Associations between diet quality and dietary patterns and gestational diabetes mellitus in a low-risk cohort of pregnant women in Australia: a cross-sectional study.

J Hum Nutr Diet. 2024-4

[2]
Bridging the Gap from Enterotypes to Personalized Dietary Recommendations: A Metabolomics Perspective on Microbiome Research.

Metabolites. 2023-12-2

[3]
Association between the Maternal Mediterranean Diet and Perinatal Outcomes: A Systematic Review and Meta-Analysis.

Adv Nutr. 2024-2

[4]
Parabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a.

Nat Commun. 2023-11-25

[5]
The influence of embryo stage on obstetric complications and perinatal outcomes following programmed compared to natural frozen-thawed embryo transfer cycles: a systematic review and meta-analysis.

Front Endocrinol (Lausanne). 2023

[6]
The curious case of .

Gut Microbes. 2023-12

[7]
The Association between Gestational Diabetes and the Microbiome: A Systematic Review and Meta-Analysis.

Microorganisms. 2023-7-4

[8]
Faecalibacterium: a bacterial genus with promising human health applications.

FEMS Microbiol Rev. 2023-7-5

[9]
Parabacteroides distasonis uses dietary inulin to suppress NASH via its metabolite pentadecanoic acid.

Nat Microbiol. 2023-8

[10]
Maternal gut microbiota in the postpartum Period: A Systematic review.

Eur J Obstet Gynecol Reprod Biol. 2023-6

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