Hahm Eunil, Jo Ahla, Kang Eunji, Yoo Kwanghee, Shin Minsup, An Jaehyun, Pham Xuanhung, Kim Hyungmo, Kang Homan, Kim Jaehi, Jun Bonghyun
Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Republic of Korea.
Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Nanomaterials (Basel). 2023 Jul 24;13(14):2145. doi: 10.3390/nano13142145.
Nanoparticles (NP) with optical properties embedded silica particles have been widely used in various fields because of their unique properties. The surfaces of optical NPs have been modified with various organic ligands to maintain their unique optical properties and colloidal stability. Among the surface modification methods, silica encapsulation of optical NPs is widely used to enhance their biocompatibility and stability. However, in the case of NPs with hydrophobic ligands on the surface, the ligands that determine the optical properties of the NPs may detach from the NPs, thereby changing the optical properties during silica encapsulation. Herein, we report a generally applicable silica encapsulation method using trimethoxy(2-phenylethyl)silane (TMPS) for non-hydrophilic optical NPs, such as quantum dots (QDs) and gold NPs. This silica encapsulation method was applied to fabricate multiple silica-encapsulated QD-embedded silica NPs (SiO@QD@SiO NPs; QD) and multiple silica-encapsulated gold NP-embedded silica NPs labeled with 2-naphthalene thiol (SiO@Au@SiO). The fabricated silica-encapsulated NPs exhibited optical properties without significant changes in the quantum yield or Raman signal intensity.
具有光学性质的纳米粒子（NP）嵌入二氧化硅颗粒，因其独特性能而在各个领域得到广泛应用。光学NP的表面已用各种有机配体进行修饰，以保持其独特的光学性质和胶体稳定性。在表面修饰方法中，光学NP的二氧化硅包封被广泛用于增强其生物相容性和稳定性。然而，对于表面带有疏水配体的NP，决定NP光学性质的配体可能会从NP上脱落，从而在二氧化硅包封过程中改变光学性质。在此，我们报告一种普遍适用的二氧化硅包封方法，该方法使用三甲氧基（2-苯乙基）硅烷（TMPS）对非亲水性光学NP，如量子点（QD）和金NP进行包封。这种二氧化硅包封方法被用于制备多个二氧化硅包封的嵌入量子点的二氧化硅纳米粒子（SiO@QD@SiO NPs；QD）以及多个用2-萘硫醇标记的二氧化硅包封的嵌入金纳米粒子（SiO@Au@SiO）。所制备的二氧化硅包封的NP表现出光学性质，量子产率或拉曼信号强度没有显著变化。
