Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China.
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming 650500, China.
Molecules. 2023 Jul 18;28(14):5480. doi: 10.3390/molecules28145480.
Wall., popularly known as "Pangpo tea", is an edible, medicinal, and ornamental plant of the Family Theaceae. The leaves of were historically applied for the treatment of liver and intestinal inflammatory diseases in China. This study aimed to explore the hepatoprotective agents from leaves through hepatoprotective and anti-inflammatory assessment. The phytochemical investigation of the leaves of resulted in the isolation and identification of a total of 18 chemical compounds, including triterpenoids, aliphatic alcohol, dihydrochalcones, chalcones, flavanols, phenolic glycoside, and lignans. Compounds -, -, -, and - were identified from for the first time. Compounds and could significantly alleviate hepatocellular damage by decreasing the contents of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and inhibit the hepatocellular apoptosis in the HepG2 cells induced by N-acetyl-p-aminophenol (APAP). In addition, compounds and inhibited reactive oxygen species (ROS) and malondialdehyde (MDA) contents and increased the catalase (CAT) superoxide dismutase (SOD), and glutathione (GSH) levels for suppressing APAP-induced oxidative stress. Additionally, compounds , , and also had significant anti-inflammatory effects by inhibiting interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) productions on LPS-induced RAW246.7 cells.
岩白菜，俗称“帕窝茶”，是山茶科可食用、药用和观赏植物。在中国，历史上曾用该植物的叶子治疗肝脏和肠道炎症性疾病。本研究旨在通过保肝和抗炎评价，从岩白菜叶子中探索保肝剂。岩白菜叶子的植物化学研究导致总共分离和鉴定了 18 种化合物，包括三萜类、脂肪醇、二氢查耳酮、查耳酮、黄烷醇、酚糖苷和木脂素。化合物-、-、-和-首次从岩白菜中鉴定出来。化合物和能够通过降低天冬氨酸氨基转移酶（AST）和丙氨酸氨基转移酶（ALT）的含量显著减轻肝细胞损伤，并抑制 N-乙酰对氨基酚（APAP）诱导的 HepG2 细胞的肝细胞凋亡。此外，化合物和抑制活性氧（ROS）和丙二醛（MDA）含量，并增加过氧化氢酶（CAT）、超氧化物歧化酶（SOD）和谷胱甘肽（GSH）水平，以抑制 APAP 诱导的氧化应激。此外，化合物、和也具有显著的抗炎作用，通过抑制 LPS 诱导的 RAW246.7 细胞中白细胞介素 6（IL-6）、白细胞介素 1β（IL-1β）和肿瘤坏死因子-α（TNF-α）的产生。
