Section of Medical Pathophysiology, Food Science and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Nutrients. 2023 Jul 14;15(14):3142. doi: 10.3390/nu15143142.
The primary control of dysmetabolic patients is extremely challenging worldwide, with inadequate dietary habits and sporadic physical activity among the key risk factors for metabolic syndrome onset. Nowadays, there is no exclusive treatment for this condition, and considering that preventive measures usually fail, new therapeutic approaches need to be proposed and investigated. This present pilot study compared the effects of diet alone and in association with a combination of myo-inositol and d-chiro-inositol in their 40:1 ratio, α-lactalbumin, and on different metabolic parameters in obese dysmetabolic patients. To this purpose, 37 patients with BMI between 30 and 40 and fasting blood glucose between 100 and 125 mg/dL were divided into two groups: () the control group followed a hypocaloric Mediterranean diet, () while the study group was also supplemented with a daily dosage of two sachets, each one containing 1950 mg myo-inositol, 50 mg d-chiro-inositol, 50 mg α-lactalbumin, and 250 mg . After a 6-month treatment, all parameters improved in both groups. Nevertheless, the treated group experienced a greater improvement, especially concerning the variation from the baseline of HOMA index, triglycerides, BMI, body weight, and waist circumference. These findings support the supplementation with myo-inositol and d-chiro-inositol in the 40:1 ratio, α-lactalbumin, and as a therapeutical strategy to potentiate the beneficial effects induced via dietary programs in dysmetabolic patients.
代谢异常患者的主要控制在全球范围内极具挑战性，不良饮食习惯和零星的体育活动是代谢综合征发病的关键危险因素。目前，尚无针对这种情况的特效治疗方法，而且考虑到预防措施通常无效，需要提出和研究新的治疗方法。本初步研究比较了单独饮食以及饮食联合肌醇和手性肌醇以 40:1 的比例、α-乳白蛋白和 对肥胖代谢异常患者不同代谢参数的影响。为此，将 37 名 BMI 在 30 至 40 之间且空腹血糖在 100 至 125mg/dL 之间的患者分为两组：()对照组遵循低热量地中海饮食，()而研究组还每天补充两袋，每袋含有 1950mg 肌醇、50mg 手性肌醇、50mgα-乳白蛋白和 250mg 。经过 6 个月的治疗，两组的所有参数都有所改善。然而，治疗组的改善更为明显，特别是在 HOMA 指数、甘油三酯、BMI、体重和腰围的基线变化方面。这些发现支持补充肌醇和手性肌醇以 40:1 的比例、α-乳白蛋白和 作为一种治疗策略，以增强饮食方案对代谢异常患者的有益作用。
