Gallo Valentina, Arienzo Alyexandra, Tomassetti Federica, Antonini Giovanni
Department of Science, Roma Tre University, Viale Guglielmo Marconi 446, 00146 Rome, Italy.
National Institute of Biostructures and Biosystems (INBB), Viale delle Medaglie d'Oro 305, 00136 Rome, Italy.
Foods. 2024 Mar 16;13(6):907. doi: 10.3390/foods13060907.
A strong correlation between the occurrence of various pathological conditions and intestinal dysbiosis is supported by a range of strong evidence. Vice versa, many pathologies have been shown, in turn, to be responsible for alterations in the gut microbiota, a condition that can worsen illness outcomes and response to therapies. For these reasons, great efforts have been made, and studies are still ongoing, to elucidate the mechanisms underlying gut microbiota alterations and to search for pharmacologic or other strategies that can effectively restore the gut microbiota. In this narrative review, we examined the most significant literature on the role of some milk bioactive compounds, such as milk oligosaccharides and whey proteins, in modulating the composition of the gut microbiota and the underlying mechanisms of action, with the aim of investigating the impact of the microbiota changes mediated by these milk bioactive molecules on human health, and their potential use as therapeutics to treat or adjuvate the treatment of gut dysbiosis and associated pathologies.
一系列有力证据支持了各种病理状况的发生与肠道菌群失调之间存在密切关联。反之，许多病理状况反过来又被证明是导致肠道微生物群改变的原因，这种情况会恶化疾病预后和对治疗的反应。出于这些原因，人们已经做出了巨大努力，并且相关研究仍在进行中，以阐明肠道微生物群改变的潜在机制，并寻找能够有效恢复肠道微生物群的药理学或其他策略。在这篇叙述性综述中，我们研究了关于一些牛奶生物活性化合物（如牛奶寡糖和乳清蛋白）在调节肠道微生物群组成及其潜在作用机制方面的最重要文献，目的是研究这些牛奶生物活性分子介导的微生物群变化对人类健康的影响，以及它们作为治疗剂治疗或辅助治疗肠道菌群失调及相关病理状况的潜在用途。
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