Yoon Jieun, Sasaki Kazunori, Nishimura Iku, Hashimoto Haruna, Okura Tomohiro, Isoda Hiroko
Institute of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8572, Japan.
Open Innovation Laboratory for Food and Medicinal Resource Engineering, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Tennodai, Tsukuba 305-8572, Japan.
Nutrients. 2023 Jul 21;15(14):3234. doi: 10.3390/nu15143234.
The Japanese population has the world's longest life expectancy but faces the challenge of extending the healthy life expectancy without developing chronic diseases. Therefore, the effectiveness of products derived from olives used in the Mediterranean diet as a potential dietary solution has attracted attention. This study examined the effects of desert olive tree pearls (DOTPs), which contain 162 times more polyphenol hydroxytyrosol than olive oil, on the cognitive function of middle-aged and older adults using the Cognitrax test. Participants (aged 51-82 years) were assigned to the DOTP intake ( = 36) or placebo group ( = 36) in a randomized, double-blind, placebo-controlled, parallel-group study. The participants received 3 g of DOTPs or placebo in olive oil twice daily for 12 weeks. Among cognitive domains, complex attention had a significant time × group interaction effect ( = 0.049) between the DOTP and placebo groups. The simple main effect for this item was significantly different ( < 0.001 and = 0.572, respectively). Time effects were significant ( < 0.05) for the psychomotor speed, reaction time, cognitive flexibility, processing speed, and executive function domains. Therefore, DOTPs have the potential to alleviate cognitive problems faced by middle-aged and older adults in Japan.
日本人口拥有世界上最长的预期寿命，但面临着在不患慢性病的情况下延长健康预期寿命的挑战。因此，地中海饮食中使用的橄榄衍生产品作为一种潜在的饮食解决方案的有效性受到了关注。本研究使用Cognitrax测试，考察了沙漠橄榄树珍珠（DOTP，其多酚羟基酪醇含量是橄榄油的162倍）对中老年人认知功能的影响。在一项随机、双盲、安慰剂对照、平行组研究中，参与者（年龄在51 - 82岁之间）被分配到DOTP摄入组（n = 36）或安慰剂组（n = 36）。参与者每天两次在橄榄油中摄入3克DOTP或安慰剂，持续12周。在认知领域中，DOTP组和安慰剂组之间，复杂注意力存在显著的时间×组间交互作用（p = 0.049）。该项目的简单主效应有显著差异（分别为p < 0.001和p = 0.572）。心理运动速度、反应时间、认知灵活性、处理速度和执行功能领域的时间效应显著（p < 0.05）。因此，DOTP有潜力缓解日本中老年人面临的认知问题。
