Department of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, via dei Vestini 31, 66100 Chieti Scalo (CH), Italy.
Biomolecules. 2019 Jul 10;9(7):271. doi: 10.3390/biom9070271.
The use of food supplements or functional food has significantly increased in the past decades, especially to compensate both the modern lifestyle and the food shortages of the industrialized countries. Despite food supplements are habitually intended to correct nutritional deficiencies or to support specific physiological functions, they are often combined with common drug therapies to improve the patient's health and/or mitigate the symptoms of many chronic diseases such as cardiovascular diseases, cystic fibrosis, cancer, liver and gastrointestinal diseases. In recent years, increased attentions are given to the patient's diet, and the use of food supplements and functional food rich in vitamins and antioxidants plays a very important role in the treatment and prevention of neurodegenerative diseases such as Parkinson's disease (PD). Natural compounds, phytochemicals, vitamins, and minerals can prevent, delay, or alleviate the clinical symptoms of PD in contrast to some of the main physiopathological mechanisms involved in the development of the disease, like oxidative stress, free radical formation, and neuroinflammation. The purpose of this review is to collect scientific evidences which support the use of specific biomolecules and biogenic elements commonly found in food supplements or functional food to improve the clinical framework of patients with PD.
在过去几十年中，食品补充剂或功能性食品的使用显著增加，尤其是为了弥补现代生活方式和工业化国家的食物短缺。尽管食品补充剂通常旨在纠正营养不足或支持特定的生理功能，但它们经常与常规药物治疗相结合，以改善患者的健康状况和/或减轻许多慢性疾病的症状，如心血管疾病、囊性纤维化、癌症、肝脏和胃肠道疾病。近年来，人们越来越关注患者的饮食，富含维生素和抗氧化剂的食品补充剂和功能性食品在治疗和预防帕金森病（PD）等神经退行性疾病方面发挥着非常重要的作用。与疾病发展过程中涉及的一些主要病理生理机制（如氧化应激、自由基形成和神经炎症）相比，天然化合物、植物化学物质、维生素和矿物质可以预防、延迟或减轻 PD 的临床症状。本综述的目的是收集支持使用常见于食品补充剂或功能性食品中的特定生物分子和生物元素来改善 PD 患者临床状况的科学证据。
