Kawabe Ayano, Uesawa Yoshihiro
Department of Medical Molecular Informatics, Meiji Pharmaceutical University, Tokyo 204-8588, Japan.
Pharmaceuticals (Basel). 2023 Jun 30;16(7):948. doi: 10.3390/ph16070948.
Glaucoma is the most common cause of blindness, which significantly reduces quality of life. Most glaucoma cases are primary glaucoma; nevertheless, many patients suffer from glaucoma caused by drugs, such as corticosteroids. A comprehensive review of the risks associated with corticosteroid-induced glaucoma is limited. Therefore, we used the Japanese Adverse Drug Event Reporting Database (JADER) published by the Pharmaceuticals and Medical Devices Agency (PMDA) to analyze the risk factors associated with glaucoma and the trends and characteristics of corticosteroid-induced glaucoma. We did not find sex or age differences associated with the onset of glaucoma. Hierarchical clustering and principal component analysis revealed that triamcinolone acetonide and betamethasone sodium phosphate, which are used around the eyes in Japan, are more likely to induce intraocular pressure (IOP) elevation compared with other corticosteroids. Increased IOP is a direct cause of glaucoma. Based on these findings, it may be necessary to limit or avoid the use of these corticosteroids.
青光眼是导致失明的最常见原因，它会显著降低生活质量。大多数青光眼病例为原发性青光眼；然而，许多患者患有由药物（如皮质类固醇）引起的青光眼。对皮质类固醇诱导性青光眼相关风险的全面综述较为有限。因此，我们利用日本药品和医疗器械管理局（PMDA）发布的日本药品不良反应报告数据库（JADER）来分析与青光眼相关的风险因素以及皮质类固醇诱导性青光眼的趋势和特征。我们未发现与青光眼发病相关的性别或年龄差异。分层聚类和主成分分析显示，在日本用于眼部周围的曲安奈德和倍他米松磷酸钠比其他皮质类固醇更有可能导致眼压（IOP）升高。眼压升高是青光眼的直接病因。基于这些发现，可能有必要限制或避免使用这些皮质类固醇。
