Galarreta-Rodriguez Itziar, Etxebeste-Mitxeltorena Mikel, Moreno Esther, Plano Daniel, Sanmartín Carmen, Megahed Saad, Feliu Neus, Parak Wolfgang J, Garaio Eneko, Gil de Muro Izaskun, Lezama Luis, Ruiz de Larramendi Idoia, Insausti Maite
Departamento Química Orgánica e Inorgánica, Facultad de Ciencia y Tecnología, University of the Basque Country (UPV/EHU), Sarriena s/n, 48940 Leioa, Spain.
Department of Pharmaceutical Technology and Chemistry, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain.
Pharmaceuticals (Basel). 2023 Jun 30;16(7):949. doi: 10.3390/ph16070949.
In recent years, much effort has been invested into developing multifunctional drug delivery systems to overcome the drawbacks of conventional carriers. Magnetic nanoparticles are not generally used as carriers but can be functionalised with several different biomolecules and their size can be tailored to present a hyperthermia response, allowing for the design of multifunctional systems which can be active in therapies. In this work, we have designed a drug carrier nanosystem based on FeO nanoparticles with large heating power and 4-amino-2-pentylselenoquinazoline as an attached drug that exhibits oxidative properties and high selectivity against a variety of cancer malignant cells. For this propose, two samples composed of homogeneous FeO nanoparticles (NPs) with different sizes, shapes, and magnetic properties have been synthesised and characterised. The surface modification of the prepared FeO nanoparticles has been developed using copolymers composed of poly(ethylene-alt-maleic anhydride), dodecylamine, polyethylene glycol and the drug 4-amino-2-pentylselenoquinazoline. The obtained nanosystems were properly characterised. Their in vitro efficacy in colon cancer cells and as magnetic hyperthermia inductors was analysed, thereby leaving the door open for their potential application as multimodal agents.
近年来，人们投入了大量精力来开发多功能药物递送系统，以克服传统载体的缺点。磁性纳米颗粒通常不作为载体使用，但可以用几种不同的生物分子进行功能化，并且其尺寸可以定制以呈现热疗响应，从而能够设计出在治疗中具有活性的多功能系统。在这项工作中，我们设计了一种基于具有大加热功率的FeO纳米颗粒和作为附着药物的4-氨基-2-戊基硒代喹唑啉的药物载体纳米系统，该药物具有氧化特性且对多种癌症恶性细胞具有高选择性。为此，合成并表征了由具有不同尺寸、形状和磁性的均匀FeO纳米颗粒（NPs）组成的两个样品。使用由聚（乙烯-alt-马来酸酐）、十二烷基胺、聚乙二醇和药物4-氨基-2-戊基硒代喹唑啉组成的共聚物对制备的FeO纳米颗粒进行了表面改性。对获得的纳米系统进行了适当的表征。分析了它们在结肠癌细胞中的体外功效以及作为磁热疗诱导剂的功效，从而为它们作为多模态试剂的潜在应用打开了大门。
