用于生物医学应用的磁性纳米粒子介导加热
Magnetic Nanoparticle-Mediated Heating for Biomedical Applications.
作者信息
Kwizera Elyahb Allie, Stewart Samantha, Mahmud Md Musavvir, He Xiaoming
机构信息
Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Fischell Department of Bioengineering, University of- Maryland, College Park, MD 20742, USA.
出版信息
J Heat Transfer. 2022 Mar;144(3). doi: 10.1115/1.4053007. Epub 2022 Jan 18.
Magnetic nanoparticles, especially superparamagnetic nanoparticles (SPIONs), have attracted tremendous attention for various biomedical applications. Facile synthesis and functionalization together with easy control of the size and shape of SPIONS to customize their unique properties, have made it possible to develop different types of SPIONs tailored for diverse functions/applications. More recently, considerable attention has been paid to the thermal effect of SPIONs for the treatment of diseases like cancer and for nanowarming of cryopreserved/banked cells, tissues, and organs. In this mini-review, recent advances on the magnetic heating effect of SPIONs for magnetothermal therapy and enhancement of cryopreservation of cells, tissues, and organs, are discussed, together with the non-magnetic heating effect (i.e., high Intensity focused ultrasound or HIFU-activated heating) of SPIONs for cancer therapy. Furthermore, challenges facing the use of magnetic nanoparticles in these biomedical applications are presented.
磁性纳米颗粒，尤其是超顺磁性纳米颗粒（SPIONs），在各种生物医学应用中引起了极大关注。SPIONs的简便合成与功能化，以及对其尺寸和形状的轻松控制以定制其独特性能，使得开发针对不同功能/应用的不同类型SPIONs成为可能。最近，人们对SPIONs在治疗癌症等疾病以及对冷冻保存/储存的细胞、组织和器官进行纳米加热方面的热效应给予了相当大的关注。在本综述中，讨论了SPIONs在磁热疗法以及增强细胞、组织和器官冷冻保存方面磁热效应的最新进展，以及SPIONs在癌症治疗中的非磁热效应（即高强度聚焦超声或HIFU激活加热）。此外，还介绍了在这些生物医学应用中使用磁性纳米颗粒所面临的挑战。
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