Zhao Yang, Zhang Haigang, Zhang Qixiong, Tao Hui
Department of Pharmaceutics, 96602 Hospital of Chinese People's Liberation Army, Kunming 650233, China.
Department of Pharmacology, College of Pharmacy, Army Medical University, Chongqing 400038, China.
Pharmaceutics. 2023 Jul 4;15(7):1881. doi: 10.3390/pharmaceutics15071881.
As the most abundant white blood cells in humans, neutrophils play a key role in acute and chronic inflammation, suggesting that these cells are a key component of targeted therapies for various inflammation-related diseases. Specific enzyme-responsive or specific ligand-modified polymer nanoparticles are beneficial for improving drug efficacy, reducing toxicity, and enhancing focal site retention. However, there remain significant challenges in biomedical applications of these synthetic polymer nanoparticles, mainly due to their rapid clearance by the reticuloendothelial system. In recent years, biomimetic drug delivery systems such as neutrophils acting directly as drug carriers or neutrophil-membrane-coated nanoparticles have received increasing attention due to the natural advantages of neutrophils. Thus, neutrophil-targeted, neutrophil-assisted, or neutrophil-coated nanoparticles exhibit a prolonged blood circulation time and improved accumulation at the site of inflammation. Despite recent advancements, further clinical research must be performed to evaluate neutrophil-based delivery systems for future biomedical application in the diagnosis and treatment of related inflammatory diseases. In this review, we have summarized new exciting developments and challenges in neutrophil-mediated drug delivery strategies for treating inflammation-related diseases.
作为人类中数量最多的白细胞，中性粒细胞在急性和慢性炎症中起关键作用，这表明这些细胞是各种炎症相关疾病靶向治疗的关键组成部分。特异性酶响应或特异性配体修饰的聚合物纳米颗粒有利于提高药物疗效、降低毒性并增强病灶部位滞留。然而，这些合成聚合物纳米颗粒在生物医学应用中仍存在重大挑战，主要是因为它们会被网状内皮系统快速清除。近年来，由于中性粒细胞的天然优势，诸如直接作为药物载体的中性粒细胞或中性粒细胞膜包被的纳米颗粒等仿生药物递送系统受到越来越多的关注。因此，靶向中性粒细胞、中性粒细胞辅助或中性粒细胞包被的纳米颗粒表现出延长的血液循环时间并改善了在炎症部位的蓄积。尽管最近取得了进展，但必须进行进一步的临床研究，以评估基于中性粒细胞的递送系统在未来生物医学中用于相关炎症性疾病诊断和治疗的应用。在本综述中，我们总结了中性粒细胞介导的治疗炎症相关疾病的药物递送策略中的新的令人兴奋的进展和挑战。
