Department of Nephrology, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China.
The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai, People's Republic of China.
Int J Nanomedicine. 2021 Nov 16;16:7663-7681. doi: 10.2147/IJN.S328705. eCollection 2021.
The chimeric trait of recruitment by inflammatory signals endows neutrophils with the functionality of migrating to inflamed tissues, which can be utilized to tailor novel drug delivery systems. In this review, we introduce a mechanism of neutrophil-derived drug delivery systems recruited into inflamed sites and provide insight into tumors and inflammation therapy. In particular, the advantages of neutrophils-their endogenous-derived neutrophil membrane, exosomes as drug carriers for augmented targeting, prolonged circulation, and improved biostability-were concluded. Subsequently, the latest application in the treatment of tumors and inflammation was elaborated upon, followed by a discussion of the future prospects to neutrophil-derived delivery systems. This promising system will provide new therapeutic avenues for the treatment of inflammation and tumors.
募集炎症信号的嵌合特性赋予中性粒细胞迁移到炎症组织的功能，可用于定制新型药物传递系统。在这篇综述中，我们介绍了一种募集到炎症部位的中性粒细胞衍生药物传递系统的机制，并深入探讨了肿瘤和炎症治疗。特别是，总结了中性粒细胞的优势——其内源性衍生的中性粒细胞膜、作为药物载体的外泌体，具有增强的靶向性、延长的循环时间和提高的生物稳定性。随后，阐述了其在肿瘤和炎症治疗中的最新应用，并讨论了中性粒细胞衍生递药系统的未来前景。这个很有前途的系统将为炎症和肿瘤的治疗提供新的治疗途径。
