Department of Medical Microbiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Department of Pathology, Microbiology & Immunology, University California Davis Veterinary Medicine, 5323 Vet Med 3A, Davis, CA 95616, USA.
Viruses. 2023 Jul 13;15(7):1546. doi: 10.3390/v15071546.
The number of identified human polyomaviruses (HPyVs) has increased steadily over the last decade. Some of the novel HPyVs have been shown to cause disease in immunocompromised individuals. The Lyon-IARC polyomavirus (LIPyV) belonging to species was identified in 2017 in skin and saliva samples from healthy individuals. Since its initial discovery, LIPyV has rarely been detected in human clinical samples but has been detected in faeces from cats with diarrhoea. Serological studies show low LIPyV seroprevalence in human populations. To investigate the possibility that LIPyV is a feline rather than a human polyomavirus, we compared serum IgG responses against the VP1 major capsid protein of LIPyV and 13 other HPyVs among cats (n = 40), dogs (n = 38) and humans (n = 87) using an in-house immunoassay. Seropositivity among cats was very high (92.5%) compared to dogs (31.6%) and humans (2.3%). Furthermore, the median antibody titres against LIPyV were 100-10,000x higher in cats compared to dogs and humans. In conclusion, the high prevalence and intensity of measured seroresponses suggest LIPyV to be a feline rather than a human polyomavirus. Whether LIPyV infection induces diarrhoea or other symptoms in cats remains to be established.
在过去的十年中，已鉴定的人类多瘤病毒 (HPyV) 的数量稳步增加。一些新型 HPyV 已被证明会在免疫功能低下的个体中引起疾病。里昂-IARC 多瘤病毒 (LIPyV) 于 2017 年在健康个体的皮肤和唾液样本中被鉴定为种。自最初发现以来，LIPyV 在人类临床样本中很少被检测到，但在患有腹泻的猫的粪便中被检测到。血清学研究显示人类群体中 LIPyV 的血清阳性率较低。为了研究 LIPyV 是否是一种猫科动物而不是人类多瘤病毒的可能性，我们使用内部免疫测定法比较了 40 只猫、38 只狗和 87 名人类血清 IgG 对 LIPyV 和其他 13 种 HPyV 的 VP1 主要衣壳蛋白的反应。与狗（31.6%）和人类（2.3%）相比，猫的血清阳性率非常高（92.5%）。此外，与狗和人类相比，猫针对 LIPyV 的抗体滴度中位数高 100-10,000 倍。总之，高流行率和强度的血清反应表明 LIPyV 是一种猫科动物而不是人类多瘤病毒。LIPyV 感染是否会引起猫的腹泻或其他症状仍有待确定。
