Unité de Recherche Génomes et Milieux (GEMI), Université de Nouakchott, Nouveau Campus Universitaire, Nouakchott BP 5026, Mauritania.
National Reference Center for Arboviruses, National Institute of Health and Medical Research (Inserm) and French Armed Forces Biomedical Research Institute (IRBA), 13005 Marseille, France.
Viruses. 2023 Jul 20;15(7):1588. doi: 10.3390/v15071588.
The presence of alphaviruses, such as chikungunya virus (CHIKV), has never been reported in Mauritania. We assessed the seroprevalence of CHIKV among Nouakchott residents. A cross-sectional study involving 1300 non-febrile patients consulting at the Nouakchott hospital center was conducted between January and June 2021. The presence of anti-CHIKV IgG and neutralizing antibodies against CHIKV, O'nyong-nyong virus (ONNV), and Semliki Forest virus (SFV) was determined by an enzyme-linked immunosorbent assay (ELISA) and a serum neutralization test, respectively, and the associated risk factors were investigated. Of the 1300 study participants, serological evidence of previous exposure to CHIKV was observed in 37 individuals (2.8%). Sex, age, reported use of repellants, and bed net ownership and usage were not associated with CHIKV seropositivity. Our results showed the co-circulation of two other alphaviruses, ONNV and SFV, in Nouakchott in 30 (2.3%) individuals. This is the first study that documents the co-circulation of CHIKV, ONNV, and SFV in Mauritania, albeit at low prevalence. Surveillance and routine testing for alphaviruses and other arboviruses in symptomatic patients should be implemented in health facilities to assess the health burden associated with these viruses. Efforts should also be made to strengthen the vector control measures.
在毛里塔尼亚从未报告过甲病毒的存在，如基孔肯雅病毒（CHIKV）。我们评估了努瓦克肖特居民中 CHIKV 的血清流行率。2021 年 1 月至 6 月期间，在努瓦克肖特医院中心对 1300 名非发热患者进行了横断面研究。通过酶联免疫吸附试验（ELISA）和血清中和试验分别确定了抗 CHIKV IgG 和针对 CHIKV、奥尼昂-昂昂病毒（ONNV）和 Semliki 森林病毒（SFV）的中和抗体的存在，并调查了相关的危险因素。在 1300 名研究参与者中，有 37 人（2.8%）有先前接触 CHIKV 的血清学证据。性别、年龄、报告使用驱虫剂以及蚊帐的拥有和使用与 CHIKV 血清阳性无关。我们的结果表明，在努瓦克肖特有另外两种甲病毒，ONNV 和 SFV，在 30 人（2.3%）中共同循环。这是首次记录在毛里塔尼亚共同循环的 CHIKV、ONNV 和 SFV 的研究，尽管流行率很低。应该在卫生机构中对症状患者进行甲病毒和其他虫媒病毒的监测和常规检测，以评估与这些病毒相关的健康负担。还应努力加强病媒控制措施。
