Department of Neurology, The First Affiliated Hospital of Jinzhou Medical University, No.2, Section.5, Renmin Street, Jinzhou, 121000, People's Republic of China.
School of Nursing, Jinzhou Medical University, Jinzhou, 121099, China.
Inflammopharmacology. 2023 Oct;31(5):2685-2699. doi: 10.1007/s10787-023-01291-0. Epub 2023 Jul 29.
Alzheimer's disease (AD) is a major neurological disease affecting elderly individuals worldwide. Existing drugs only reduce the symptoms of the disease without addressing the underlying causes. Commonly, Aβ25-35 peptide aggregation is the main reason for AD development. Recently, the discovery of multiple protein-targeting molecules has provided a new strategy for treating AD. This study demonstrates the neuroprotective potential of oxymatrine against multiple mechanisms, such as acetylcholinesterase, mitochondrial damage, and β-amyloid-induced cell toxicity. The in vitro cell culture studies showed that oxymatrine possesses significant potential to inhibit acetylcholine esterase and promotes antioxidant, antiapoptotic effects while preventing Aβ25-35 peptide aggregation in PC12 cells. Furthermore, oxymatrine protects PC12 cells against Aβ25-35-induced cytotoxicity and down-regulates the reactive oxygen species generation. The in vivo acute toxicological studies confirm the safety of oxymatrine without causing organ damage or death in animals. Overall, this study provided evidence that oxymatrine is an efficient neuroprotective agent, with a potential to be a multifunctional drug for Alzheimer's disease treatment. These findings present a reliable and synergistic approach for treating AD.
阿尔茨海默病（AD）是一种影响全球老年人的主要神经退行性疾病。现有的药物只能减轻疾病的症状，而不能解决根本原因。通常，Aβ25-35 肽聚集是 AD 发展的主要原因。最近，多种靶向蛋白的分子的发现为 AD 的治疗提供了新的策略。本研究表明氧化苦参碱对多种机制具有神经保护作用，如乙酰胆碱酯酶、线粒体损伤和β-淀粉样蛋白诱导的细胞毒性。体外细胞培养研究表明，氧化苦参碱具有显著抑制乙酰胆碱酯酶的潜力，并能促进抗氧化、抗凋亡作用，同时防止 PC12 细胞中 Aβ25-35 肽的聚集。此外，氧化苦参碱能保护 PC12 细胞免受 Aβ25-35 诱导的细胞毒性，并下调活性氧的产生。体内急性毒理学研究证实氧化苦参碱是安全的，不会导致动物器官损伤或死亡。总的来说，这项研究提供了氧化苦参碱是一种有效的神经保护剂的证据，有潜力成为治疗阿尔茨海默病的多功能药物。这些发现为治疗 AD 提供了一种可靠的协同方法。
