Department of Spinal Surgery, Weifang People's Hospital, Weifang, Shandong, PR China.
Department of Spinal Surgery, Weifang People's Hospital, Weifang, Shandong, PR China.
Clinics (Sao Paulo). 2023 Jul 27;78:100236. doi: 10.1016/j.clinsp.2023.100236. eCollection 2023.
To evaluate the effects of exercise training on neurological recovery, Growth Transforming Factor-β1 (TGF-β1), Hypoxia Inducible Factor-1α (HIF-1α), and Nogo-NgR signaling pathways after spinal cord injury in rats.
Forty-eight male Sprague-Dawley rats were randomly divided into four groups: normal group, sham-operated group, model group, and training group. The rat spinal cord injury model was established using Allen's method, and the training group received exercise training on the 8th day postoperatively. The Basso, Beattie and Bresnahan (BBB) score, modified Tarlow score, and inclined plane test scores were compared in each group before injury and 1, 7, 14, 21 and 28 days after injury.
The BBB score and modified Tarlow score of the model group and the training group were 0 at the first day after the injury, and gradually increased on the seventh day onwards (p < 0.05). The BBB score and modified Tarlow score of the training group were higher than those of the model group at the 14th, 21st and 28th day (p < 0.05). The angles of the inclined plate at multiple time points after injury were lower in the model group and the training group than in the normal group and the sham-operated group (p < 0.05); The angles of the inclined plate at the 14th, 21st and 28th day after injury were higher in the training group than in the model group (p < 0.05).
The mechanism of exercise training may be connected to the inhibition of the Nogo-NgR signaling pathway to promote neuronal growth.
评估运动训练对大鼠脊髓损伤后神经功能恢复、生长转化因子-β1（TGF-β1）、缺氧诱导因子-1α（HIF-1α）和 Nogo-NgR 信号通路的影响。
48 只雄性 Sprague-Dawley 大鼠随机分为 4 组：正常组、假手术组、模型组和训练组。采用 Allen 法建立大鼠脊髓损伤模型，术后第 8 天训练组进行运动训练。比较各组大鼠损伤前及损伤后 1、7、14、21 和 28 天的 Basso、Beattie 和 Bresnahan（BBB）评分、改良 Tarlow 评分和斜板试验评分。
模型组和训练组大鼠在损伤后第 1 天 BBB 评分和改良 Tarlow 评分均为 0，第 7 天开始逐渐升高（p < 0.05）。训练组大鼠在第 14、21 和 28 天的 BBB 评分和改良 Tarlow 评分均高于模型组（p < 0.05）。损伤后多个时间点斜板试验的角度在模型组和训练组均低于正常组和假手术组（p < 0.05）；训练组在第 14、21 和 28 天的斜板试验角度均高于模型组（p < 0.05）。
运动训练的机制可能与抑制 Nogo-NgR 信号通路，促进神经元生长有关。
