Department of Medicine, University of Barcelona, Barcelona, Spain; Department of Psychiatry, Santa Maria University Hospital Lleida, Lleida, Spain; Institut de Recerca Biomèdica de Lleida (IRBLleida), Spain.
Department of Medicine, University of Barcelona, Barcelona, Spain; Barcelona Clínic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clínic de Barcelona, CIBERSAM, IDIBAPS, Barcelona, Spain.
J Psychiatr Res. 2023 Sep;165:191-196. doi: 10.1016/j.jpsychires.2023.07.023. Epub 2023 Jul 19.
C-reactive protein (CRP) and inflammatory ratios have been proposed to study immune dysregulation in schizophrenia. Nevertheless, links between CRP and inflammatory ratios in acute SCZ inpatients have been understudied. This study investigated the relationship between CRP and inflammatory ratios (Neutrophil-Lymphocyte Ratio [NRL], Platelet-Lymphocyte Ratio [PLR], Monocyte-Lymphocyte ratio [MLR] and Basophil-Lymphocyte Ratio [BLR]) in a total of 698 acute SCZ inpatients; and analysed how this relationship is affected by sex and type of episode. CRP correlated with NLR (r = 0.338, p < 0.001), PLR (r = 0.271, p < 0.001) and MLR (r = 0.148, p < 0.001) but not with BLR (r = 0.059, p = 0.121). Multiple lineal regression analysis showed that high levels of NLR, MLR and PLR but not BLR were independently associated with high CRP levels. No sex-related variations were found. Significant associations were maintained for NLR and MLR in first-episode and multiepisode SCZ, although the strength of the association was stronger in multiepisode SCZ. Again, no sex-related differences were found in these associations. In conclusion, inflammatory ratios were low to moderately associated with CRP in acute SCZ inpatients. NLR and multiepisode SCZ showed the highest associations with CRP. Future studies should consider inflammatory ratios not as a substitute for CRP but as a complementary biomarker.
C-反应蛋白（CRP）和炎症比值已被提出用于研究精神分裂症中的免疫失调。然而，急性精神分裂症住院患者中 CRP 和炎症比值之间的联系尚未得到充分研究。本研究共调查了 698 名急性精神分裂症住院患者中 CRP 与炎症比值（中性粒细胞-淋巴细胞比值[NLR]、血小板-淋巴细胞比值[PLR]、单核细胞-淋巴细胞比值[MLR]和嗜碱性粒细胞-淋巴细胞比值[BLR]）之间的关系，并分析了这种关系如何受到性别和发作类型的影响。CRP 与 NLR（r=0.338，p<0.001）、PLR（r=0.271，p<0.001）和 MLR（r=0.148，p<0.001）相关，但与 BLR 不相关（r=0.059，p=0.121）。多元线性回归分析显示，高 NLR、MLR 和 PLR 水平而不是 BLR 水平与 CRP 水平升高独立相关。未发现性别相关的变化。在首发和反复发作精神分裂症中，NLR 和 MLR 与 CRP 之间仍存在显著关联，尽管在反复发作精神分裂症中关联强度更强。同样，这些关联在性别方面没有差异。总之，炎症比值与急性精神分裂症住院患者中的 CRP 低度至中度相关。NLR 和反复发作精神分裂症与 CRP 的相关性最高。未来的研究应考虑将炎症比值不仅作为 CRP 的替代物，而且作为补充生物标志物。
