Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York, USA.
Department of Forensic Pathology, Office of Chief Medical Examiner, New York City, New York, USA.
Am J Transplant. 2023 Dec;23(12):1995-1999. doi: 10.1016/j.ajt.2023.07.017. Epub 2023 Jul 28.
In 2022, a global outbreak of mpox (formerly known as monkeypox) was reported outside of areas considered endemic for the disease, predominantly in persons identifying as men who have sex with men, gay, or bisexual. To date, 3 cases of mpox in solid organ transplant recipients have been published; however, no instances of secondary transmission among solid organ transplant recipients have been reported. Here, we report a case of a 53-year-old male kidney transplant recipient who contracted mpox while caring for a household contact with the disease. The patient's clinical and laboratory findings during his rapidly fatal course, autopsy findings, and genomics analysis are presented, emphasizing the need for expanded pre-exposure prophylaxis efforts in patient populations without the risk factors prioritized by public health authorities for vaccination.
2022 年，在被认为是该疾病地方性流行的地区以外，出现了猴痘（以前称为猴痘）的全球爆发，主要发生在被认定为男男性行为者、同性恋或双性恋的人群中。迄今为止，已发表了 3 例实体器官移植受者感染猴痘的病例；然而，尚未报告实体器官移植受者之间的二次传播病例。在这里，我们报告了一名 53 岁男性肾移植受者的病例，该患者在照顾家中有该病接触者时感染了猴痘。患者在快速致命病程中的临床和实验室发现、尸检结果和基因组学分析均被呈现，这强调了需要在没有公共卫生部门优先接种疫苗的风险因素的患者人群中扩大暴露前预防措施。
