Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Neuroscience. 2023 Sep 15;528:64-74. doi: 10.1016/j.neuroscience.2023.07.027. Epub 2023 Jul 28.
The glymphatic system is important for waste removal in the central nervous system. It removes soluble proteins and metabolic waste under the action of aquaporin-4 (AQP4) at the end of astrocytes. The glymphatic system plays a role in numerous neurological diseases; however, the relationship between migraine and the glymphatic system remains unclear. In this study, we explored the relationship between the glymphatic system and migraine using the nitroglycerin migraine model in C57/BL6mice. The glymphatic influx of cerebrospinal fluid tracer was reduced in mice in the migraine model, accompanied by decreased expression and impaired polarization of AQP4, thereby suggesting glymphatic dysfunction in migraine mice model. Then, further suppression of glymphatic function by TGN-020 (an AQP4 blocker) aggravated the migraine pathological changes in mice. The results indicated that glymphatic dysfunction may aggravate migraine pathology. Therefore, our findings revealed the potential role of the glymphatic system in migraine, providing possible targets for migraine prevention and treatment.
血-脑屏障系统对于中枢神经系统的废物清除非常重要。它在星形胶质细胞末端的水通道蛋白 4（AQP4）的作用下，清除可溶性蛋白和代谢废物。血-脑屏障系统在许多神经疾病中发挥作用；然而，偏头痛与血-脑屏障系统之间的关系尚不清楚。在这项研究中，我们使用 C57/BL6 小鼠的硝酸甘油偏头痛模型来探讨血-脑屏障系统与偏头痛之间的关系。偏头痛模型小鼠的脑脊液示踪剂的血-脑屏障内流减少，同时 AQP4 的表达和极化受损，提示偏头痛小鼠模型中存在血-脑屏障功能障碍。然后，通过 TGN-020（AQP4 阻断剂）进一步抑制血-脑屏障功能会加重小鼠的偏头痛病理变化。这些结果表明，血-脑屏障功能障碍可能会加重偏头痛的病理变化。因此，我们的研究结果揭示了血-脑屏障系统在偏头痛中的潜在作用，为偏头痛的预防和治疗提供了可能的靶点。
