靶向巨噬细胞行为在创伤愈合中的策略的最新进展。
Recent advances in strategies to target the behavior of macrophages in wound healing.
机构信息
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
出版信息
Biomed Pharmacother. 2023 Sep;165:115199. doi: 10.1016/j.biopha.2023.115199. Epub 2023 Jul 28.
Chronic wounds and scar formation are widespread due to limited suitable remedies. The macrophage is a crucial regulator in wound healing, controlling the onset and termination of inflammation and regulating other processes related to wound healing. The current breakthroughs in developing new medications and drug delivery methods have enabled the accurate targeting of macrophages in oncology and rheumatic disease therapies through clinical trials. These successes have cleared the way to utilize drugs targeting macrophages in various disorders. This review thus summarizes macrophage involvement in normal and pathologic wound healing. It further details the targets available for macrophage intervention and therapeutic strategies for targeting the behavior of macrophages in tissue repair and regeneration.
由于缺乏有效的治疗方法，慢性伤口和瘢痕形成较为常见。巨噬细胞是伤口愈合过程中的关键调控者，能够控制炎症的发生和终止，并调节与伤口愈合相关的其他过程。目前，新药物和药物输送方法的突破使得通过临床试验能够在肿瘤学和风湿性疾病治疗中精确靶向巨噬细胞。这些成功为利用针对各种疾病的巨噬细胞药物铺平了道路。因此，本综述总结了巨噬细胞在正常和病理性伤口愈合中的作用。进一步详细介绍了可用于干预巨噬细胞的靶点以及靶向组织修复和再生中巨噬细胞行为的治疗策略。
Zotero 插件