Department of Ophthalmology, Sancaktepe Sehit Prof. Dr. Ilhan Varank Training and Research Hospital, Istanbul, Turkey.
Department of Opticianry, Vocational School of Health Services, Istanbul Gelisim University, Istanbul, Turkey.
Photodiagnosis Photodyn Ther. 2023 Sep;43:103724. doi: 10.1016/j.pdpdt.2023.103724. Epub 2023 Jul 29.
Obesity is known to be a significant risk factor for many ocular diseases. In order to understand the mechanism of obesity-related ocular diseases, we examined the lamina cribrosa morphology, peripapillary choroidal thickness (PPCT), and macular choroidal thickness (MCT) in obese women using optical coherence tomography (OCT).
This comparative cross-sectional study included the right eyes of 72 obese women and 63 healthy women classified based on body mass index (BMI). Each participant underwent a thorough ophthalmological examination and enhanced depth (EDI) OCT imaging, including measurements of PPCT from a total of 12 regions, MCT from a total of 7 regions, Bruch's membrane opening (BMO), lamina cribrosa thickness (LCT), lamina cribrosa depth (LCD), intraocular pressure (IOP), and central corneal thickness (CCT).
The mean age and BMI of the obese group were 32.36±7.38 years and 35.11±4.39 kg/m², while those of the control group were 31.64±7.78 years and 20.88±1.72 kg/m² (p = 0.658, and p<0.001, respectively). PPCT N1000, PPCT N1500, PPCT S1500, and PPCT T1500 were statistically significantly thinner in the obese group than the control group (p values were 0.039, 0.012, 0.027, and 0.036, respectively). IOP and CCT were significantly higher in the obese group than the control group (p = 0.016, and p = 0.019, respectively). There was no statistically significant difference between the two groups in terms of MCT, BMO, LCT, and LCD.
We discovered thinning in the PPCT, which indicates microvascular abnormalities in the optic disc head. Microvascular alteration in the peripapillary region may be a potential initial event in the pathogenesis of several obesity-related ocular diseases, especially glaucoma.
肥胖是许多眼部疾病的重要危险因素。为了了解肥胖相关眼病的发病机制，我们使用光学相干断层扫描（OCT）检查了肥胖女性的颅神经筛板形态、视盘周围脉络膜厚度（PPCT）和黄斑脉络膜厚度（MCT）。
这是一项比较性的横断面研究，纳入了 72 名肥胖女性和 63 名健康女性的右眼，这些女性是根据体重指数（BMI）分类的。每位参与者都接受了全面的眼科检查和增强深度成像（EDI）OCT 检查，包括总共 12 个区域的 PPCT、总共 7 个区域的 MCT、Bruch 膜开口（BMO）、颅神经筛板厚度（LCT）、颅神经筛板深度（LCD）、眼压（IOP）和中央角膜厚度（CCT）的测量。
肥胖组的平均年龄和 BMI 分别为 32.36±7.38 岁和 35.11±4.39 kg/m²，而对照组的平均年龄和 BMI 分别为 31.64±7.78 岁和 20.88±1.72 kg/m²（p=0.658，p<0.001）。与对照组相比，肥胖组的 PPCT N1000、PPCT N1500、PPCT S1500 和 PPCT T1500 均明显变薄（p 值分别为 0.039、0.012、0.027 和 0.036）。肥胖组的 IOP 和 CCT 明显高于对照组（p=0.016 和 p=0.019）。两组间的 MCT、BMO、LCT 和 LCD 无统计学差异。
我们发现 PPCT 变薄，提示视盘头部微血管异常。视盘周围区域的微血管改变可能是几种肥胖相关眼病，尤其是青光眼发病机制中的一个潜在初始事件。
