School of Pharmacy, Naval Medical University (Second Military Medical University), Shanghai 200433, China; School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Department of Pharmacy, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 201999, China.
Chin J Nat Med. 2023 Jul;21(7):483-498. doi: 10.1016/S1875-5364(23)60405-4.
Insomnia is a common sleep disorder without effective therapy and can affect a person's life. The mechanism of the disease is not completely understood. Hence, there is a need to understand the targets related to insomnia, in order to develop innovative therapies and new compounds. Recently, increasing interest has been focused on complementary and alternative medicines for treating or preventing insomnia. Research into their molecular components has revealed that their sedative and sleep-promoting properties rely on the interactions with various neurotransmitter systems in the brain. In this review, the role of 5-hydroxytryptamine (5-HT) in insomnia development is summarized, while a systematic analysis of studies is conducted to assess the mechanisms of herbal medicines on different 5-HT receptors subtypes, in order to provide reference for subsequent research.
失眠是一种常见的睡眠障碍，目前尚无有效的治疗方法，可影响人的生活。其发病机制尚未完全阐明。因此，需要了解与失眠相关的靶点，以便开发创新疗法和新化合物。最近，人们对用于治疗或预防失眠的补充和替代药物越来越感兴趣。对其分子成分的研究表明，它们的镇静和促眠作用依赖于与大脑中各种神经递质系统的相互作用。本综述总结了 5-羟色胺（5-HT）在失眠发病中的作用，并对不同 5-HT 受体亚型的中草药作用机制进行系统分析，为后续研究提供参考。
