从益母草的地上部分中分离得到的新型双环螺环[4.5]癸烷二萜。
New di-spirocyclic labdane diterpenoids from the aerial parts of Leonurus japonicus.
机构信息
School of Biological Science and Technology, University of Jinan, Jinan 250022, China.
School of Biological Science and Technology, University of Jinan, Jinan 250022, China.
出版信息
Chin J Nat Med. 2023 Jul;21(7):551-560. doi: 10.1016/S1875-5364(23)60446-7.
Phytochemical investigation on the ethanol extract of a well-known medicinal herb Leonurus japonicus, led to the separation of 18 labdane type diterpenoids (1-18). Through comprehensive spectroscopic analyses and quantum chemical calculations, these compounds were structurally characterized as six new interesting 5,5,5-di-spirocyclic ones (1-6), two new (7 and 8) and six known (13-18) interesting 6,5,5-di-spirocyclic ones, a new rare 14,15-dinor derivative (9), and three new ones incorporating a γ-lactone unit (10-12). An in vitro neuroprotective assay in RSC96 cells revealed that compounds 7 and 12 exhibited neuroprotective activity in a concentration-dependent way, comparable to the reference drug N-acetylcysteine.
从一种著名的药用植物益母草（Leonurus japonicus）的乙醇提取物中进行植物化学研究，导致分离出 18 种拉巴烷型二萜（1-18）。通过全面的光谱分析和量子化学计算，这些化合物的结构特征被确定为六种新的有趣的 5,5,5-双环型（1-6），两种新的（7 和 8）和六种已知的（13-18）有趣的 6,5,5-双环型，一种新的罕见的 14,15-二降衍生物（9），以及三种新的包含γ-内酯单元的化合物（10-12）。在 RSC96 细胞中的体外神经保护测定表明，化合物 7 和 12 以浓度依赖的方式表现出神经保护活性，与参考药物 N-乙酰半胱氨酸相当。
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