School of Biological Science and Technology, University of Jinan, Jinan 250022, China.
School of Biological Science and Technology, University of Jinan, Jinan 250022, China.
Chin J Nat Med. 2023 Jul;21(7):551-560. doi: 10.1016/S1875-5364(23)60446-7.
Phytochemical investigation on the ethanol extract of a well-known medicinal herb Leonurus japonicus, led to the separation of 18 labdane type diterpenoids (1-18). Through comprehensive spectroscopic analyses and quantum chemical calculations, these compounds were structurally characterized as six new interesting 5,5,5-di-spirocyclic ones (1-6), two new (7 and 8) and six known (13-18) interesting 6,5,5-di-spirocyclic ones, a new rare 14,15-dinor derivative (9), and three new ones incorporating a γ-lactone unit (10-12). An in vitro neuroprotective assay in RSC96 cells revealed that compounds 7 and 12 exhibited neuroprotective activity in a concentration-dependent way, comparable to the reference drug N-acetylcysteine.
从一种著名的药用植物益母草（Leonurus japonicus）的乙醇提取物中进行植物化学研究，导致分离出 18 种拉巴烷型二萜（1-18）。通过全面的光谱分析和量子化学计算，这些化合物的结构特征被确定为六种新的有趣的 5,5,5-双环型（1-6），两种新的（7 和 8）和六种已知的（13-18）有趣的 6,5,5-双环型，一种新的罕见的 14,15-二降衍生物（9），以及三种新的包含γ-内酯单元的化合物（10-12）。在 RSC96 细胞中的体外神经保护测定表明，化合物 7 和 12 以浓度依赖的方式表现出神经保护活性，与参考药物 N-乙酰半胱氨酸相当。
