State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, People's Republic of China.
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, People's Republic of China.
Phytochemistry. 2020 Apr;172:112280. doi: 10.1016/j.phytochem.2020.112280. Epub 2020 Feb 7.
Ten highly oxygenated diterpenoids (nine undescribed ones) were isolated from the aerial parts of Leonurus japonicus Houtt. 14,15-Dinor-labd-5,8-dien-3,13-dione was a 14,15-dinor-labdane diterpenoid possessing a C skeleton. 7β,9α-Dihydroxy-6-oxo-labd-13-en-15,16-amide represented a rare example of labdane diterpenoid featuring an α,β-unsaturated-γ-lactam moiety. The structures of all compounds were elucidated using spectroscopic data analyses and comparisons. The effects of these obtained compounds on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW 264.7 cells were evaluated.(10R*,13R*,15R*)-15,16-Epoxy-6,13-dihydroxy-15-methoxy-labda-5,8-dien-7-one inhibited NO production with an IC value of 40.1 μM.
从益母草地上部分分离得到 10 个高度氧化的二萜（9 个为新化合物）。14,15-二降-劳布-5,8-二烯-3,13-二酮是一个 14,15-二降-劳布烷二萜，具有 C 骨架。7β,9α-二羟基-6-酮-劳布-13-烯-15,16-酰胺代表了劳布烷二萜中罕见的具有α,β-不饱和-γ-内酰胺部分的实例。所有化合物的结构均通过光谱数据分析和比较进行了阐明。评估了这些获得的化合物对脂多糖（LPS）诱导的 RAW 264.7 细胞中一氧化氮（NO）产生的影响。（10R*,13R*,15R*）-15,16-环氧-6,13-二羟基-15-甲氧基-劳布-5,8-二烯-7-酮对 NO 产生的抑制作用，IC 值为 40.1 μM。
