Li Jiahang, Niu Lihang, Huang Hong, Li Qing, Xie Chunfeng, Yang Cheng
State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin, 300353, China; Tianjin International Joint Academy of Biomedicine, Tianjin, 300457, China.
State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin, 300353, China.
Phytochemistry. 2024 Jan;217:113927. doi: 10.1016/j.phytochem.2023.113927. Epub 2023 Nov 11.
Eleven undescribed labdane diterpenoids, sibiricusins K-U, and seven known analogues were obtained from the MeOH extract of the aerial parts of Leonurus sibiricus. The structures of the compounds were established by detailed spectroscopic data analysis, single-crystal X-ray diffraction analysis and ECD calculations. Among them, sibiricusins L-N featured a rare α, β-unsaturated-γ-lactam moiety. Fourteen of the isolates were evaluated for their anti-inflammatory effect on the production of NO in LPS-induced RAW264.7 cells through Griess assay. Sibiricusin O displayed the strongest activity with an IC value of 9.0 ± 1.7 μM.
从益母草地上部分的甲醇提取物中获得了11个未描述的半日花烷二萜类化合物，即西伯利亚素K-U，以及7个已知类似物。通过详细的光谱数据分析、单晶X射线衍射分析和电子圆二色计算确定了这些化合物的结构。其中，西伯利亚素L-N具有罕见的α,β-不饱和-γ-内酰胺部分。通过Griess法评估了14种分离物对脂多糖诱导的RAW264.7细胞中一氧化氮产生的抗炎作用。西伯利亚素O表现出最强的活性，IC值为9.0±1.7μM。
