Efficacy of toltrazuril in the prevention of coccidiosis in naturally infected lambs on pasture.

The efficacy of toltrazuril (Bay Vi 9142) in preventing ovine coccidiosis due to an infection acquired immediately after turnout on pasture was evaluated by comparing the faecal consistency, weight gain, and oocyst output of treated and untreated lambs in 3 trials. The lambs were either given a single treatment with toltrazuril at 15 or 20 mg/kg, or they were given a dose of 10 mg/kg on 2 separate days. A single treatment with toltrazuril at 20 mg/kg on day 10 after turnout on pasture almost completely prevented coccidiosis in 2 trials. In a third trial the acute phase of a severe Nematodirus battus infection coincided with the outbreak of coccidiosis, and thus partly masked the clinical effect of the anticoccidial treatment. In lambs treated with toltrazuril at 15 mg/kg on day 10 after turnout, the coccidial infection caused a softening of the faeces, but the lambs were not severely affected by the coccidia. In lambs given a dose of 10 mg/kg of toltrazuril twice, either on days 10 and 11 after turnout, or on days 10 and 20, the coccidial infection caused a softening af the faeces, including some cases of diarrhoea. Oocyst production due to the initial coccidial infection on pasture was markedly reduced by all treatments with toltrazuril. The reduction was most pronounced after a dose of 20 mg/kg. Lambs treated with single doses of 15 or 20 mg/kg of toltrazuril had a better weight gain than the untreated controls in 2 of the trials. Lambs treated with toltrazuril on day 10 after turnout were partially resistant to the coccidial reinfection acquired immediately after treatment, and they had a similar level of immunity as the untreated controls to the subsequent reinfection on pasture.