Experimental chemotherapy of mammalian coccidiosis with Bay g 7183.

Bay g 7183, a substituted sym. triazintrione derivative has a known high efficacy against poultry coccidia. Experimental investigations using the mouse coccidia E. falciformis indicated an activity also against mammalian coccidia. Minimum effective daily doses range between 0.25 to 10 mg/kg. Eimeria species used: E. falciformis (mouse(, E. contorta (rat), E. chinchillae (Mastomys), E. irresidua, E. magna, E. media, E. perforans, E. stiedae (rabbit), E. ashata, E. arloingi, E. faurei, E. ninakohlyakimovi, E. parva (sheep). A very appropriate mode of treatment, e.g. for rabbits is the dermal one (pour on) beside the oral route by using a stomach tube or with medicated food. Bay g 7183 is active both on schizogonic stages and gamonts. This explains the high efficacy even of single doses. If given e.g. once weekly it prevents or stops development of even massive experimental infections and their clinical symptoms. The value of E. falciformis as a test model is discussed.