Razali Khairiah, Mohamed Wael M Y
Department of Basic Medical Sciences, Kulliyyah of Medicine, International Islamic University Malaysia (IIUM), 25200 Kuantan, Pahang, Malaysia.
Clinical Pharmacology Department, Menoufia Medical School, Menoufia University, 32511 Menoufia, Egypt.
J Integr Neurosci. 2023 Jul 4;22(4):87. doi: 10.31083/j.jin2204087.
Parkinson's disease (PD), the most prevalent motoric neurodegenerative disease, has been intensively studied to better comprehend its complicated pathogenesis. Chronic neuroinflammation is a major factor contributing to the development of PD. Reportedly, high-mobility group box 1 (HMGB1) protein is capable of mediating neuroinflammatory response. In this regard, knowledge mapping of the research linking HMGB1 to PD is necessary.
Herein, we perform a dynamic and longitudinal bibliometric analysis to explore the hotspots and current trends of HMGB1-related PD publications during the past decade.
All PD publications focusing on HMGB1 protein were retrieved from the PubMed database using the search terms "Parkinson's disease" and "hmgb1". Using filters, only English articles published between 2011 and 2022 were selected. The Bibliometrix and Biblioshiny packages from R software were used to conduct the bibliometric analysis.
The filtered search identified 47 articles (34 original articles and 13 review articles), published between 2011 and 2022. There was an increase trend in the number of articles published, with an annual growth rate of 19.35 percent. In terms of research and scientific collaboration in this field, the United States is in the lead, followed by China, Malaysia, and Australia. Compared to other countries, the United States and China had the highest level of collaboration in this research area. Neuroinflammation, microglia, and receptor for advanced glycation end-products (RAGE) represent the top three frontiers and hotspots for HMGB1-related PD research. According to the thematic evolution analysis, over the last decade, PD, HMGB1 and microglia were addressed individually, however, since 2017, these topics were frequently discussed within the same cluster: neuroinflammation. Furthermore, PD, HMGB1, and neuroinflammation domains co-occurred in majority of the research discussion.
The link between HMGB1 and PD was realized a decade ago and becomes increasingly important over time. Our findings can aid scholars in comprehending the global context of HMGB1/PD relationship and provide significant insights for future PD research.
帕金森病（PD）是最常见的运动性神经退行性疾病，人们对其进行了深入研究以更好地理解其复杂的发病机制。慢性神经炎症是导致PD发展的主要因素。据报道，高迁移率族蛋白B1（HMGB1）能够介导神经炎症反应。在这方面，有必要对将HMGB1与PD联系起来的研究进行知识图谱分析。
在此，我们进行动态和纵向的文献计量分析，以探索过去十年中与HMGB1相关的PD出版物的热点和当前趋势。
使用搜索词“帕金森病”和“hmgb1”从PubMed数据库中检索所有关注HMGB1蛋白的PD出版物。通过筛选，仅选择2011年至2022年期间发表的英文文章。使用R软件中的Bibliometrix和Biblioshiny包进行文献计量分析。
经过筛选的搜索共识别出47篇文章（34篇原创文章和13篇综述文章），发表于2011年至2022年之间。发表文章的数量呈增长趋势，年增长率为19.35%。在该领域的研究和科学合作方面，美国领先，其次是中国、马来西亚和澳大利亚。与其他国家相比，美国和中国在该研究领域的合作水平最高。神经炎症、小胶质细胞和晚期糖基化终产物受体（RAGE）是与HMGB1相关的PD研究的前三大前沿和热点。根据主题演变分析，在过去十年中，PD、HMGB1和小胶质细胞是分别进行讨论的，然而，自2017年以来，这些主题经常在同一集群中被讨论：神经炎症。此外，在大多数研究讨论中，PD、HMGB1和神经炎症领域同时出现。
HMGB1与PD之间的联系在十年前就已被认识到，并且随着时间的推移变得越来越重要。我们的研究结果可以帮助学者理解HMGB1/PD关系的全球背景，并为未来的PD研究提供重要的见解。
