Chen Lingshan, Chen Jianfei, Wu Min, Yan Pingkang, Zhou Xueping
Medical Laboratory Specialty, The Second Hospital of Jinhua, Jinhua, Zhejiang Province, China.
School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China.
Front Neurol. 2024 Mar 7;15:1343303. doi: 10.3389/fneur.2024.1343303. eCollection 2024.
Parkinson's disease (PD), characterized by the loss of dopaminergic neurons, is a progressive neurodegenerative disorder. Recent research has revealed a significant connection between gut microbiota and PD. To gain insight into research interests, disciplinary contexts, and potential future directions, a comprehensive bibliometric analysis was conducted on the brain-gut axis and PD literature published between 2014 and 2023.
Relevant literature records were gathered from the Web of Science Core Collection on August 11, 2023. The data were then analyzed by Biblioshiny R packages and VOSviewer (version 1.6.19).
The dataset revealed an upward trend in annual scientific publications on the brain-gut axis and PD, with an annual growth rate of 50.24%. China, the United States, and Italy were the top three most productive countries/regions. The journal "International Journal Of Molecular Sciences" published the most articles, while "Movement Disorders" received the highest number of citations. Professor Keshavarzian A emerged as the most prolific author, while Professor Scheperjans F held the highest h-index. Keyword analysis highlighted "alpha-synuclein" as the most frequent term, with "mouse model," "inflammation," and "risk" as emerging research topics. Additionally, "central nervous system" and "intestinal bacterial overgrowth" attracted increasing attention.
This study examined current trends and hotspots in the bibliometric landscape of the brain-gut axis and PD research. Future research directions should explore the functional and metabolic activities of gut microbiota. Additionally, transitioning from observational to interventional study designs offers the potential for personalized interventions and disease prediction. These findings can guide researchers in navigating the latest developments and shaping the future directions of this field.
帕金森病（PD）是一种以多巴胺能神经元丧失为特征的进行性神经退行性疾病。最近的研究揭示了肠道微生物群与PD之间的重要联系。为了深入了解研究兴趣、学科背景和潜在的未来方向，对2014年至2023年发表的关于脑-肠轴与PD的文献进行了全面的文献计量分析。
于2023年8月11日从科学网核心合集收集相关文献记录。然后使用Biblioshiny R包和VOSviewer（版本1.6.19）对数据进行分析。
数据集显示，关于脑-肠轴与PD的年度科学出版物呈上升趋势，年增长率为50.24%。中国、美国和意大利是发文量最高的三个国家/地区。《国际分子科学杂志》发表的文章最多，而《运动障碍》获得的引用次数最多。凯沙瓦尔齐安·A教授是发文量最多的作者，而舍佩尔扬斯·F教授的h指数最高。关键词分析突出显示“α-突触核蛋白”是最常见的术语，“小鼠模型”“炎症”和“风险”是新兴的研究主题。此外，“中枢神经系统”和“肠道细菌过度生长”也受到越来越多的关注。
本研究考察了脑-肠轴与PD研究文献计量格局的当前趋势和热点。未来的研究方向应探索肠道微生物群的功能和代谢活动。此外，从观察性研究设计向干预性研究设计的转变为个性化干预和疾病预测提供了潜力。这些发现可以指导研究人员了解该领域的最新进展并塑造其未来方向。
