Department of Botany, SBN Government PG College, Barwani (M.P), India.
Department of Pharmacology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, Republic of Korea.
Curr Pharm Des. 2023;29(22):1729-1740. doi: 10.2174/1381612829666230731102634.
Cancer is a collection of diseases in which aberrant cells grow uncontrolled and invade surrounding tissues. Cancer can be classified as carcinoma, sarcoma, leukemia, or lymphoma. The deadliest cancers are lung, breast, colorectal, pancreatic, and prostate. Chemotherapy, surgery, and radiotherapy are the usual cancer treatments. However, drug resistance poses a significant barrier to cancer treatment. Macroalgae are wellknown producers of bioactive compounds with antimicrobial, antioxidant, anti-inflammatory, and anti-cancer properties. Red algae, in particular, are a prominent source of bioactive substances, such as polysaccharides, phenolic compounds, lipids, sterols, alkaloids, and terpenoids. Therefore, molecules from marine resources could be an appealing way to identify new cancer treatment alternatives. This study aimed to provide a brief overview of what is currently known regarding the potential of red macroalgae in cancer treatment by discussing the primary therapeutic targets of the disease and identifying compounds or extracts with bioactive characteristics against them.
癌症是一组疾病，其中异常细胞生长失控并侵犯周围组织。癌症可以分为癌、肉瘤、白血病或淋巴瘤。最致命的癌症是肺癌、乳腺癌、结直肠癌、胰腺癌和前列腺癌。化疗、手术和放疗是常见的癌症治疗方法。然而，耐药性是癌症治疗的一个重大障碍。大型藻类是具有抗菌、抗氧化、抗炎和抗癌特性的生物活性化合物的知名生产者。红藻是生物活性物质的主要来源，如多糖、酚类化合物、脂质、固醇、生物碱和萜类化合物。因此，来自海洋资源的分子可能是一种有吸引力的方法，可以识别新的癌症治疗替代品。本研究旨在通过讨论疾病的主要治疗靶点，并确定针对这些靶点具有生物活性特征的化合物或提取物，简要概述红大型藻类在癌症治疗方面的潜力。
