Salim Henna Palampadiyan, Mallikarjun Shanthala B, Raju Shashidara, Surendranath Austin R
Department of Pedodontics and Preventive Dentistry, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India.
Department of Oral Pathology and Microbiology, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India.
Int J Clin Pediatr Dent. 2023 Mar-Apr;16(2):259-263. doi: 10.5005/jp-journals-10005-2527.
The oral probiotic M18 (S M18) offers the potential to confer oral health benefits as it produces bacteriocins which are targeting .
The purpose of this clinical trial was to assess the effect of S M18 probiotics on salivary and to identify the correlation between dental caries with salivary count.
This clinical trial was conducted in 40 children between the age-group 3-6 years, subjects were randomly selected and the decay extracted filled (due to caries) (def score) was recorded. The presalivary unstimulated saliva was collected and subjected to microbiological examination for counts, salivary pH, and buffering capacity. Children were divided into two groups as the control and the experimental group. bacteriocin like inhibitory substances M18 (M18 is a strain number) (BLIS M18) probiotic was administered in the experimental group, and unsweetened lozenge as a placebo in the control group for 7 days and postsalivary samples were collected and subjected to microbiological examinations for count, salivary pH, and buffering capacity.
A significant decrease in the counts were noticed, an increase in buffering capacity, and no significant change in pH was observed after the intervention of S M18. A linear correlation was observed between the def score and count.
This clinical trial revealed that S M18 in its 7 days regime can lead to the inhibition of counts favorably in the oral cavity by affecting salivary pH and buffering capacity.
Salim HP, Mallikarjun SB, Raju S, Randomized Clinical Trial of Oral Probiotic M18 on Salivary in Preprimary Children. Int J Clin Pediatr Dent 2023;16(2):259-263.
口服益生菌M18（SM18）具有提供口腔健康益处的潜力，因为它能产生具有靶向作用的细菌素。
本临床试验的目的是评估SM18益生菌对唾液的影响，并确定龋齿与唾液计数之间的相关性。
本临床试验在40名3至6岁的儿童中进行，随机选择受试者并记录龋失补牙数（由于龋齿）（def评分）。收集非刺激性的腮腺唾液并进行微生物学检查，以检测计数、唾液pH值和缓冲能力。儿童被分为对照组和实验组。实验组给予细菌素样抑制物质M18（M18是菌株编号）（BLIS M18）益生菌，对照组给予无糖含片作为安慰剂，为期7天，之后收集唾液样本并进行微生物学检查，检测计数、唾液pH值和缓冲能力。
在SM18干预后，计数显著下降，缓冲能力增加，pH值未观察到显著变化。观察到def评分与计数之间存在线性相关性。
本临床试验表明，SM18在7天的疗程中可通过影响唾液pH值和缓冲能力，在口腔中有效抑制计数。
Salim HP, Mallikarjun SB, Raju S, 口服益生菌M18对学龄前儿童唾液的随机临床试验。《国际临床儿科牙科学杂志》2023；16(2):259 - 263。
