Nilchian Firoozeh, Esrafili Mohammadreza, Hosseini Nafiseh
Department of Oral Public Health, Dental Materials Research Center, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Student Research Committee, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Dent Res J (Isfahan). 2024 Jul 12;21:39. eCollection 2024.
Various methods, including the use of probiotics, have been suggested to prevent caries. Caries, which is mainly caused by , is one of the bacterial diseases that imposes a heavy cost on society. The present study was conducted to investigate the probiotic products available in Iranian pharmacies that are used for caries prevention.
In this double-blind randomized clinical trial, 40 students of medicine and pharmacy were randomly allocated to two equal groups of intervention and control using random allocation software. The intervention group used a probiotic pill containing M18 and K12 bacteria every night before going to bed. The control group used a mouth freshener tablet with the same flavor as the probiotic tablet every night before going to bed. The data were analyzed by SPSS (version 24) software using descriptive statistics (central tendency and dispersion) and inferential statistics (paired -test and independent -test). Data were collected using Excel software, and statistical analyses were performed by SPSS software (version 24).
The mean number of in the intervention group was 754.5 cfu/mm before the intervention and 1701.5 cfu/mm after the intervention, which showed a statistically significant difference ( < 0.05). In the control group, the mean was 683 cfu/mm at the beginning of the intervention and 659 cfu/mm at the end of the intervention, which did not indicate a statistically significant difference ( > 0.05). Moreover, the normality of data was checked by the Kolmogorov-Smirnov test.
The mean number of bacteria in the group using probiotic tablets was significantly increased compared to those of the control group. However, further studies are suggested to evaluate these products.
已提出多种方法，包括使用益生菌来预防龋齿。龋齿主要由 引起，是给社会带来沉重负担的细菌性疾病之一。本研究旨在调查伊朗药店中可用于预防龋齿的益生菌产品。
在这项双盲随机临床试验中，使用随机分配软件将40名医科和药学专业学生随机分为两组，即干预组和对照组，每组人数相等。干预组每晚睡前服用一片含有 M18和K12细菌的益生菌药丸。对照组每晚睡前服用一片与益生菌片味道相同的口香片。数据通过SPSS（版本24）软件进行分析，使用描述性统计（集中趋势和离散度）和推断性统计（配对 -检验和独立 -检验）。数据使用Excel软件收集，统计分析由SPSS软件（版本24）进行。
干预组干预前 的平均数量为754.5 cfu/mm，干预后为1701.5 cfu/mm，差异具有统计学意义（ < 0.05）。对照组干预开始时的平均 为683 cfu/mm，干预结束时为659 cfu/mm，差异无统计学意义（ > 0.05）。此外，通过Kolmogorov-Smirnov检验检查数据的正态性。
与对照组相比，使用益生菌片组的 细菌平均数量显著增加。然而，建议进一步研究以评估这些产品。
