Allaker Robert P, Stephen Abish S
Institute of Dentistry, Queen Mary University of London, London, UK.
Curr Oral Health Rep. 2017;4(4):309-318. doi: 10.1007/s40496-017-0159-6. Epub 2017 Oct 19.
The purpose of this study is to critically assess recent studies concerning the use of probiotics to control periodontal diseases, dental caries and halitosis (oral malodour).
Clinical studies have shown that probiotics when allied to conventional periodontal treatment can ameliorate microbial dysbiosis and produce significant improvement in clinical indicators of disease. However, this effect is often not maintained by the host after the end of probiotic use. Current probiotics also show limited effects in treating caries and halitosis. Novel approaches based up on replacement therapy and using highly abundant health-associated oral species, including nitrate-reducing bacteria, have been proposed to improve persistence of probiotic strains and maintain oral health benefits.
Probiotics have potential in the management of multifactorial diseases such as the periodontal diseases and caries, by more effectively addressing the host-microbial interface to restore homeostasis that may not be achieved with conventional treatments.
本研究旨在严格评估近期有关使用益生菌控制牙周疾病、龋齿和口臭（口腔异味）的研究。
临床研究表明，益生菌与传统牙周治疗联合使用时，可改善微生物群落失调，并使疾病的临床指标得到显著改善。然而，在停止使用益生菌后，宿主往往无法维持这种效果。目前的益生菌在治疗龋齿和口臭方面也显示出有限的效果。基于替代疗法和使用高度丰富的与健康相关的口腔菌种（包括硝酸盐还原菌）的新方法已被提出，以提高益生菌菌株的持久性并维持口腔健康益处。
益生菌在管理牙周疾病和龋齿等多因素疾病方面具有潜力，通过更有效地解决宿主-微生物界面问题来恢复内环境稳定，而这可能是传统治疗无法实现的。
