Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, PR China.
Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, PR China.
J Hazard Mater. 2022 Jun 15;432:128662. doi: 10.1016/j.jhazmat.2022.128662. Epub 2022 Mar 12.
The surface arrangements of nanomaterials can regulate their electronic structure, which will tune physicochemical properties of materials to various applications. In this study, two CuS nanosheets with (304) and (224) exposed facets were synthesized, respectively, and their antibacterial activity of different facets for replacing antibiotics to solve seriously drug-resistant bacteria were further measured. Experimental and theoretical computation results unveiled that CuS with (224) exposed facet exhibited excellent antibacterial activity through synergetic photodynamic and photothermal therapy against Gram-positive Bacillus subtilis, Gram-negative Escherichia coli and drug-resistant Pseudomonas aeruginosa under near-infrared light (808 nm) irradiation. Furthermore, the antibacterial agents strongly inhibit mouse skin infection by drug-resistant Pseudomonas aeruginosa cells. The findings provide an efficient antibacterial strategy and might advance the method of designing and producing highly effective antibacterial nanomaterials through facet engineering.
纳米材料的表面排列可以调节其电子结构，从而调整材料的物理化学性质以适用于各种应用。在这项研究中，分别合成了具有（304）和（224）暴露晶面的两种 CuS 纳米片，并进一步测量了它们不同晶面替代抗生素以解决严重抗药性细菌的抗菌活性。实验和理论计算结果表明，CuS 具有（224）暴露晶面，在近红外光（808nm）照射下，通过协同光动力和光热疗法，对革兰氏阳性枯草芽孢杆菌、革兰氏阴性大肠杆菌和抗药性铜绿假单胞菌表现出优异的抗菌活性。此外，这些抗菌剂强烈抑制了抗药性铜绿假单胞菌细胞对小鼠皮肤的感染。这些发现提供了一种有效的抗菌策略，并可能通过晶面工程推进设计和生产高效抗菌纳米材料的方法。
