College of Chemistry and Chemical Engineering, Henan Key Laboratory of Function-Oriented Porous Materials, Luoyang Normal University, Luoyang 471934, PR China.
College of Chemistry and Chemical Engineering, Henan Polytechnic University Henan Key Laboratory of Coal Green Conversion, Henan Polytechnic University, Jiaozuo 454000, PR China.
Inorg Chem. 2022 Jun 20;61(24):9328-9338. doi: 10.1021/acs.inorgchem.2c01091. Epub 2022 Jun 6.
Two-dimensional (2D) metal-organic framework (MOF) nanosheets have been demonstrated to be promising templates for the growth of various kinds of nanomaterials on their surfaces to construct novel 2D composites, thus realizing enhanced performance in various applications. Herein, we report the growth of CuO nanoparticles on 2D Zr-ferrocene (Zr-Fc)-MOF (Zr-Fc-MOF) nanosheets to prepare 2D composites for near-infrared (NIR) photothermally enhanced chemodynamic antibacterial therapy. The uniform Zr-Fc-MOF nanosheets are synthesized using the solvothermal method, followed by ultrasound sonication, and CuO nanoparticles are then deposited on its surface to obtain the CuO-decorated Zr-Fc-MOF (denoted as CuO/Zr-Fc-MOF) 2D composite. Promisingly, the CuO/Zr-Fc-MOF composite shows higher chemodynamic activity for producing ·OH via Fenton-like reaction than that of the pristine Zr-Fc-MOF nanosheets. More importantly, the chemodynamic activity of the CuO/Zr-Fc-MOF composite can be further enhanced by the photothermal effect though NIR laser (808 nm) irradiation. Thus, the CuO/Zr-Fc-MOF composite can be used as an efficient nanoagent for photothermally enhanced chemodynamic antibacterial therapy.
二维（2D）金属-有机骨架（MOF）纳米片已被证明是在其表面上生长各种纳米材料的有前途的模板，以构建新型 2D 复合材料，从而在各种应用中实现增强的性能。在此，我们报告了氧化铜纳米颗粒在二维二茂铁锆（Zr-Fc）-MOF（Zr-Fc-MOF）纳米片上的生长，以制备用于近红外（NIR）光热增强化学动力学抗菌治疗的 2D 复合材料。使用溶剂热法合成均匀的 Zr-Fc-MOF 纳米片，然后进行超声处理，然后在其表面沉积氧化铜纳米颗粒以获得氧化铜修饰的 Zr-Fc-MOF（表示为 CuO/Zr-Fc-MOF）2D 复合材料。有希望的是，CuO/Zr-Fc-MOF 复合材料通过类 Fenton 反应产生·OH 的化学动力学活性高于原始 Zr-Fc-MOF 纳米片。更重要的是，CuO/Zr-Fc-MOF 复合材料的化学动力学活性可以通过 NIR 激光（808nm）照射的光热效应进一步增强。因此，CuO/Zr-Fc-MOF 复合材料可用作光热增强化学动力学抗菌治疗的有效纳米试剂。
