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劳拉西泮治疗难治性新生儿惊厥:一项初步研究。

Lorazepam in the treatment of refractory neonatal seizures. A pilot study.

作者信息

Deshmukh A, Wittert W, Schnitzler E, Mangurten H H

出版信息

Am J Dis Child. 1986 Oct;140(10):1042-4. doi: 10.1001/archpedi.1986.02140240088032.

DOI:10.1001/archpedi.1986.02140240088032
PMID:3752014
Abstract

Seven neonatal patients with severe seizures unresponsive to conventional anticonvulsant therapy were treated with lorazepam. Immediate cessation of seizure activity occurred in all patients within five minutes. Although seizures recurred in two infants eight hours later, frequency and severity diminished. There were no apparent significant side effects attributed to the medication.

摘要

七名患有严重癫痫发作且对传统抗惊厥治疗无反应的新生儿患者接受了劳拉西泮治疗。所有患者在五分钟内均立即停止了癫痫活动。尽管有两名婴儿在八小时后癫痫复发,但发作频率和严重程度有所减轻。未发现该药物有明显的显著副作用。

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1
Lorazepam in the treatment of refractory neonatal seizures. A pilot study.劳拉西泮治疗难治性新生儿惊厥:一项初步研究。
Am J Dis Child. 1986 Oct;140(10):1042-4. doi: 10.1001/archpedi.1986.02140240088032.
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Lorazepam in the treatment of refractory neonatal seizures.
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Neonatal seizures: multicenter variability in current treatment practices.新生儿惊厥:当前治疗实践中的多中心差异
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Lorazepam: a controlled trial in patients with intractable partial complex seizures.劳拉西泮:难治性部分性复杂性癫痫患者的对照试验。
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Survey of treatment practices for neonatal seizures.新生儿惊厥治疗实践调查。
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Myoclonus associated with lorazepam therapy in very-low-birth-weight infants.极低出生体重儿中与劳拉西泮治疗相关的肌阵挛
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Anti-seizure medications for neonates with seizures.抗癫痫药物治疗新生儿癫痫。
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Pharmacotherapy for Neonatal Seizures: Current Knowledge and Future Perspectives.新生儿癫痫的药物治疗:当前知识和未来展望。
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Pharmacological treatment of neonatal seizures: a systematic review.新生儿惊厥的药物治疗:一项系统综述
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Pharmacokinetics and clinical efficacy of lorazepam in children with severe malaria and convulsions.劳拉西泮在重症疟疾伴惊厥儿童中的药代动力学及临床疗效
Br J Clin Pharmacol. 2008 Jan;65(1):12-21. doi: 10.1111/j.1365-2125.2007.02966.x. Epub 2007 Jul 17.
6
Neonatal Seizures.新生儿惊厥
Curr Treat Options Neurol. 2001 May;3(3):237-248. doi: 10.1007/s11940-001-0005-x.
7
A comparative review of the adverse effects of anticonvulsants in children with epilepsy.癫痫患儿抗惊厥药物不良反应的比较性综述。
Drug Saf. 1996 Dec;15(6):378-93. doi: 10.2165/00002018-199615060-00003.
8
Midazolam: an effective intravenous agent for seizure control.咪达唑仑:一种有效的用于控制癫痫发作的静脉用药。
Arch Emerg Med. 1987 Sep;4(3):169-72. doi: 10.1136/emj.4.3.169.