Department of Oral and Maxillofacial Surgery, University Hospital Regensburg, Regensburg, Germany.
Expert Opin Biol Ther. 2023 Jan-Jun;23(6):527-537. doi: 10.1080/14712598.2023.2208268. Epub 2023 May 1.
Human dental stem cells are promising for tooth repair because of their differentiation potential. In 2018, this journal published a report on dental stem cell treatment options that had been attempted since the early 2000s. Although it is very difficult to follow every trend since then, new achievements have been made in the last 5 years. This review summarizes selected developments in dental stem cell research.
This article provides an overview of new developments with human dental stem cells and parts of these cells like extracellular vesicles for regenerative medicine. Preclinical research, clinical trials, and other works in the field of dental stem cells research for whole tooth engineering, dental pulp regeneration, periodontitis, and tooth root regeneration are summarized. In addition, works with dental stem cells for the regeneration of diseases that cannot be cured with the regeneration of dental tissues, such as diabetes, will be presented.
Over the past five years, a number of studies using dental stem cells have improved new strategies for tooth repair. In addition, there are new dental stem cell products such as extracellular vesicles which, in combination with findings from basic research, will lead to new treatment options in the future.
由于具有分化潜能，人类牙髓干细胞有望用于牙齿修复。本杂志曾在 2018 年发表过一篇报告，其中概述了自 21 世纪初以来尝试过的各种牙髓干细胞治疗方案。虽然此后很难跟踪每一项研究进展，但在过去 5 年中已经取得了新的成果。本综述总结了牙髓干细胞研究中选定的新进展。
本文概述了人类牙髓干细胞及其细胞外囊泡等部分的新进展，这些进展可用于再生医学。总结了牙髓干细胞在全牙工程、牙髓再生、牙周炎和牙根再生领域的临床前研究、临床试验和其他研究工作。此外，还介绍了使用牙髓干细胞再生无法通过牙组织再生治愈的疾病的相关研究，如糖尿病。
在过去五年中，大量使用牙髓干细胞的研究为牙齿修复提出了新的策略。此外，还有一些新的牙髓干细胞产品，如细胞外囊泡，结合基础研究的发现，将为未来带来新的治疗选择。
