Hodge S E, Boehnke M
Am J Hum Genet. 1986 Aug;39(2):274-81.
We consider sequential sampling of pedigrees for genetic analysis. Cannings and Thompson (1977) gave simple, general guidelines for valid sequential sampling schemes. We show that their formulation of the likelihood contains an error, which is, however, easily corrected so as to maintain the validity of the sequential scheme. We also point out that although sequential and fixed-structure pedigree sampling do have the same likelihoods (as Cannings and Thompson showed), and therefore yield the same maximum likelihood point estimates of genetic parameters, they do not necessarily yield the same significance tests or confidence intervals.
我们考虑对系谱进行序贯抽样以进行遗传分析。坎宁斯和汤普森（1977年）给出了有效序贯抽样方案的简单通用准则。我们表明，他们对似然性的表述存在一个错误，不过，这个错误很容易纠正，以保持序贯方案的有效性。我们还指出，尽管序贯系谱抽样和固定结构系谱抽样确实具有相同的似然性（正如坎宁斯和汤普森所表明的那样），因此会产生相同的遗传参数最大似然点估计，但它们不一定会产生相同的显著性检验或置信区间。
