Cerón Blanco N, Rodríguez Quintana J H, Valencia Mendoza M C, Forero Botero C A, Rodríguez L C, Carrillo Villa S, Gómez Mazuera A M, Angarita Díaz J A, Uribe García B, Bermúdez Riveros C C, Alban J
Universidad del Rosario, Bogotá, Colombia.
Residente de Neurología, Fundación Cardioinfantil Instituto de Cardiologia, Bogotá, Colombia.
Neurol Perspect. 2022 Oct-Dec;2(4):232-239. doi: 10.1016/j.neurop.2022.06.004. Epub 2022 Jun 30.
SARS-CoV-2 infection has been associated with multiple neurological manifestations. One such manifestation, which has been described since the early stages of the COVID-19 pandemic and is relevant for current neurological practice, is Guillain-Barré syndrome (GBS). The literature describes neurotoxic mechanisms of the virus itself and the possible pathways by which it may affect the peripheral nerves in experimental studies; however, we still lack information on the mechanisms causing the immune response that gives rise to GBS in the context of SARS-CoV-2 infection. Colombia is one of the Latin American countries worst affected by the pandemic, with the third-highest number of cases in the region; thus, it is essential to recognise GBS, as this potential postinfectious complication may severely compromise the patient's functional status in the absence of timely diagnosis and treatment. We present a series of 12 cases of GBS associated with SARS-CoV-2 infection from hospitals in 4 different Colombian cities and describe the clinical presentation, laboratory and electrophysiological study findings, and treatment.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染与多种神经系统表现相关。自2019冠状病毒病（COVID-19）大流行早期以来就已被描述的一种此类表现，且与当前神经科临床实践相关的，是吉兰-巴雷综合征（GBS）。文献描述了病毒本身的神经毒性机制以及在实验研究中其可能影响周围神经的途径；然而，我们仍然缺乏关于在SARS-CoV-2感染背景下引发GBS的免疫反应机制的信息。哥伦比亚是受该大流行影响最严重的拉丁美洲国家之一，在该地区病例数排名第三；因此，认识GBS至关重要，因为这种潜在的感染后并发症若未得到及时诊断和治疗，可能会严重损害患者的功能状态。我们展示了来自哥伦比亚4个不同城市医院的12例与SARS-CoV-2感染相关的GBS病例系列，并描述了临床表现、实验室及电生理研究结果以及治疗情况。
