Jabs D A, Johns C J
Am J Ophthalmol. 1986 Sep 15;102(3):297-301. doi: 10.1016/0002-9394(86)90001-2.
Although spontaneous remissions often occur in sarcoidosis, chronic persistent disabling disease is also observed. Of a series of 183 patients with chronic sarcoidosis, 47 (26%) had ophthalmic involvement. In this series, chronic sarcoid was defined as disease for a minimum of five years. Patients were followed primarily for their systemic disease for a mean of 13 years. Uveitis developed in 35 patients (19%) and was an early manifestation in 32 (91%). The course of the ocular disease did not necessarily parallel that of the systemic disease. Despite the chronic nature of the underlying disease, the anterior uveitis did not pursue a chronic course in 15 of 33 patients (45%) and was generally characterized by a single episode at the onset of disease. Chronic uveitis and secondary glaucoma were poor prognostic signs, as eight of 11 patients with uveitis and glaucoma suffered severe visual loss.
虽然结节病常出现自发缓解，但也会观察到慢性持续性致残疾病。在一系列183例慢性结节病患者中，47例（26%）有眼部受累。在该系列中，慢性结节病被定义为病程至少5年的疾病。患者主要因其全身性疾病接受了平均13年的随访。35例患者（19%）发生了葡萄膜炎，其中32例（91%）为早期表现。眼部疾病的病程不一定与全身性疾病的病程平行。尽管基础疾病具有慢性性质，但33例患者中有15例（45%）的前葡萄膜炎并未呈慢性病程，且通常在疾病发作时表现为单次发作。慢性葡萄膜炎和继发性青光眼是预后不良的体征，因为11例患有葡萄膜炎和青光眼的患者中有8例出现了严重视力丧失。
