Güntekin Bahar, Erdal Furkan, Bölükbaş Burcu, Hanoğlu Lütfü, Yener Görsev, Duygun Rümeysa
Department of Biophysics, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
Research Institute for Health Sciences and Technologies (SABITA), Istanbul Medipol University, Istanbul, Turkey.
Cogn Neurodyn. 2023 Aug;17(4):829-844. doi: 10.1007/s11571-022-09873-4. Epub 2022 Sep 30.
Alzheimer's disease (AD) is an important brain disease associated with aging. It involves various functional and structural changes which alter the EEG characteristics. Although numerous studies have found changes in delta, theta, alpha, and beta power, fewer studies have looked at the changes in the resting state EEG gamma activity characteristics in AD. This study aimed to investigate the alterations in the frequency and power values of AD patients' resting-state EEG gamma oscillations compared with healthy elderly and young subjects. We performed Fast Fourier Transform (FFT) on the resting state EEG data from 179 participants, including 59 early stage AD patients, 60 healthy elderly, and 60 healthy young subjects. We averaged FFT performed epochs to investigate the power values in the gamma frequency range (28-48 Hz). We then sorted the peaks of power values in the gamma frequency range, and the average of the identified highest three values was named as the gamma dominant peak frequency. The gamma dominant peak frequency of AD patients ( = 33.4 Hz, = 32.7 Hz) was lower than healthy elderly ( = 35.5 Hz, = 35.0 Hz) and healthy young subjects ( = 37.2 Hz, = 37.0 Hz). These results could be related to AD progression and therefore critical for the recent findings regarding the 40 Hz gamma entrainment because it seems they entrain the gamma frequency of AD towards that of healthy young.
The online version contains supplementary material available at 10.1007/s11571-022-09873-4.
阿尔茨海默病（AD）是一种与衰老相关的重要脑部疾病。它涉及各种功能和结构变化，这些变化会改变脑电图特征。尽管大量研究发现了δ、θ、α和β波功率的变化，但较少有研究关注AD患者静息状态脑电图γ活动特征的变化。本研究旨在调查与健康老年人和年轻人相比，AD患者静息状态脑电图γ振荡的频率和功率值的改变。我们对179名参与者的静息状态脑电图数据进行了快速傅里叶变换（FFT），其中包括59名早期AD患者、60名健康老年人和60名健康年轻人。我们对FFT执行的各时段进行平均，以研究γ频率范围（28 - 48赫兹）内的功率值。然后我们对γ频率范围内的功率值峰值进行排序，将确定的最高三个值的平均值命名为γ主导峰值频率。AD患者的γ主导峰值频率（= 33.4赫兹，= 32.7赫兹）低于健康老年人（= 35.5赫兹，= 35.0赫兹）和健康年轻人（= 37.2赫兹，= 37.0赫兹）。这些结果可能与AD的进展有关，因此对于最近关于40赫兹γ夹带的发现至关重要，因为它们似乎将AD的γ频率夹带至健康年轻人的γ频率。
在线版本包含可在10.1007/s11571 - 022 - 09873 - 4获取的补充材料。
