有氧运动对糖尿病前期患者的影响：系统评价和荟萃分析。
Effects of aerobic exercises in prediabetes patients: a systematic review and meta-analysis.
机构信息
College of Physical Education and Health, Guangxi Normal University, Guilin, China.
School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.
出版信息
Front Endocrinol (Lausanne). 2023 Jul 13;14:1227489. doi: 10.3389/fendo.2023.1227489. eCollection 2023.
AIMS
To evaluate the effects of different durations of continuous aerobic exercise on prediabetic patients.
MATERIALS AND METHODS
The research encompassed randomized controlled trials that examined how various durations of aerobic exercise training affected outcomes related to Body Mass Index (BMI), Fasting blood glucose (FBG), 2-hour plasma glucose (2hPG), and glycated hemoglobin (HbA1c) in individuals diagnosed with prediabetes. PubMed, Embase, Web of Science, and the Cochrane Library were searched as of January 7, 2023. The Cochrane Risk of Bias, version 2 (ROB 2) tool was used to assess the risk of bias.
RESULTS
A total of 10 RCTs with 815 prediabetic patients were included. The average age of the participants was 56.1 years, with a standard deviation of 5.1 years. Among the participants, 39.2% were male. The interventions consisted of aerobic dance, treadmill running, walking, and a combination of aerobic exercises. The training sessions occurred three or four times per week. In prediabetic patients, aerobic exercise demonstrated a significant reduction in BMI compared to the control group, with a weighted mean difference (WMD) of -1.44 kg/m (95% confidence interval [CI] -1.89, -0.98). There was a decrease in FBG levels, with WMD of -0.51 mmol/L (95% CI -0.70, -0.32). Additionally, aerobic training led to significant improvements in 2hPG levels, with a WMD of -0.76 mmol/L (95% CI -1.14, -0.38). Furthermore, prediabetic patients showed a decrease in HbA1c levels after engaging in aerobic training compared to the control group, with a WMD of -0.34% (95% CI -0.45, -0.23).
CONCLUSION
In summary, engaging in aerobic exercise can have a significant positive impact on glycemic levels in individuals with prediabetes. It can also lead to reductions in BMI, FBG, 2hPG, HbA1c, and other relevant indicators. The extent of these improvements may vary slightly depending on the duration of the aerobic exercise intervention.
SYSTEMATIC REVIEW REGISTRATION
PROSPERO https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023395515.
目的
评估不同持续时间的连续有氧运动对糖尿病前期患者的影响。
材料与方法
本研究纳入了随机对照试验，旨在探讨不同时间长度的有氧运动训练对糖尿病前期患者的体重指数（BMI）、空腹血糖（FBG）、2 小时血浆葡萄糖（2hPG）和糖化血红蛋白（HbA1c）等相关结局的影响。研究检索了截至 2023 年 1 月 7 日的 PubMed、Embase、Web of Science 和 Cochrane Library。使用 Cochrane 偏倚风险评估工具（版本 2，ROB 2）评估偏倚风险。
结果
共纳入 10 项 RCT，包含 815 例糖尿病前期患者。参与者的平均年龄为 56.1 岁，标准差为 5.1 岁。参与者中 39.2%为男性。干预措施包括有氧舞蹈、跑步机跑步、步行和有氧运动的组合。训练次数为每周 3 或 4 次。与对照组相比，有氧运动显著降低了糖尿病前期患者的 BMI，加权均数差（WMD）为-1.44kg/m²（95%置信区间 [CI] -1.89，-0.98）。FBG 水平也有所下降，WMD 为-0.51mmol/L（95%CI -0.70，-0.32）。此外，有氧运动训练使 2hPG 水平显著改善，WMD 为-0.76mmol/L（95%CI -1.14，-0.38）。此外，与对照组相比，糖尿病前期患者在进行有氧运动训练后 HbA1c 水平降低，WMD 为-0.34%（95%CI -0.45，-0.23）。
结论
总之，有氧运动可以显著改善糖尿病前期患者的血糖水平，还可以降低 BMI、FBG、2hPG、HbA1c 和其他相关指标。这些改善的程度可能会因有氧运动干预的持续时间而略有不同。
系统评价注册
PROSPERO（https://www.crd.york.ac.uk/PROSPERO/），注册编号为 CRD42023395515。
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