ALTERED LEVELS OF ANTI-MULLERIAN HORMONE AND HEPCIDIN AS POTENTIAL BIOMARKERS FOR POLYCYSTIC OVARY SYNDROME.

Polycystic Ovary Syndrome (PCOS) is one of the most common endocrinopathies in women of reproductive age group. Aim - to determine the relationship of Anti-Mullerian hormone (AMH) with hepcidin, ferritin, serum iron and interleukin-6 among PCOS women. A total of 60 PCOS women enrolled in the study, whose ages ranges were between 15-45 years old versus control group (30 healthy volunteer females with regular menstrual cycles aged between 15 to 45 years). All PCOS patients and healthy control underwent full physical examination and anthropometric measurements. Blood samples were collected from each woman for measurement of AMH, and hepcidin. The study showed that the Lowest mean of hepcidin was observed among PCOS women (13.27±1.46 ng/ml) as compared to the control group of non-PCOS women (98.76±2.88 ng/ml). The mean SD of AMH in PCOS women was (7.63±3.66 ng/ml), which was significantly higher than the control group with a mean SD of (2.09±1.11 ng/ml). Based on the study findings, women with PCOS had significantly higher average serum iron levels compared to the control group (223.5±57.3 and 129.1±44.9 g/dl), serum ferritin levels were significantly elevated in women with PCOS (279.9±44.9 and 129.1±44.9 ng/ml). The mean level of hepcidin was (14.77±1.31 ng/ml) in overweight PCOS women, which was elevated significantly than in PCOS women with normal BMI (12.18±1.58 /ml). The study found a negative correlation of serum hepcidin with each iron, ferritin and AMH among PCOS women.