Pluta Dagmara, Staśczak Alicja, Stokowy Tomasz, Migacz Maciej, Kochman Klaudia, Holecki Michał
Department of Gynecological Endocrinology, School of Medicine in Katowice, Medical University of Silesia, Medyków 14, 40-752 Katowice, Poland.
Department of Systems Biology and Engineering, Faculty of Automatic Control, Electronics and Computer Science, Silesian University of Technology, Akademicka 16, 44-100 Gliwice, Poland.
Biomedicines. 2025 Aug 16;13(8):1997. doi: 10.3390/biomedicines13081997.
Polycystic ovary syndrome (PCOS) is a hormonal disorder with complex, multifactorial and still not fully explained etiopathogenesis. It is believed that the cause is a combination of genetic and environmental factors. : With the aim to better understand PCOS etiology, the study examines body composition and compares the occurrence of lipid disorders and visceral adipose tissue depending on the adopted Rotterdam phenotypes. The study included 242 patients classified into four classic Rotterdam phenotypes. Clinical data from patients were collected and carefully analyzed to determine the relationship between the occurrence of lipid disorders and the visceral adiposity index (VAI). The results obtained after assessing the differences between the Rotterdam phenotypes were not statistically significant. Differences in the levels of coefficients included in the VAI equation in the given phenotypes were also analyzed, as follows: waist circumference (-value = 0.3415), BMI (-value = 0.7112), TG [mmol/L] (-value = 0.5341) and HDL [mmol/L] (-value = 0.2302). None of the differences were statistically significant. Although the results did not show a clear association between VAI and the individual Rotterdam PCOS phenotypes, this coefficient can be used in the assessment of cardiometabolic risk in women with PCOS regardless of the adopted classification.
多囊卵巢综合征(PCOS)是一种激素紊乱疾病,其病因复杂、多因素且尚未完全阐明。人们认为其病因是遗传和环境因素的综合作用。:为了更好地理解PCOS的病因,该研究检查了身体成分,并根据采用的鹿特丹分型比较了脂质紊乱和内脏脂肪组织的发生率。该研究纳入了242例分为四种经典鹿特丹分型的患者。收集并仔细分析了患者的临床数据,以确定脂质紊乱的发生率与内脏肥胖指数(VAI)之间的关系。评估鹿特丹分型之间的差异后获得的结果无统计学意义。还分析了给定分型中VAI方程所含系数水平的差异,如下:腰围(-值 = 0.3415)、体重指数(-值 = 0.7112)、甘油三酯[mmol/L](-值 = 0.5341)和高密度脂蛋白[mmol/L](-值 = 0.2302)。这些差异均无统计学意义。尽管结果未显示VAI与个体鹿特丹PCOS分型之间存在明确关联,但无论采用何种分类,该系数均可用于评估PCOS女性的心脏代谢风险。